Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-24T12:14:58.515Z Has data issue: false hasContentIssue false
  • English
  • Français

The fine genetic structure of the pabal region of Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

Obaid H. Siddiqi
Obaid H. Siddiqi
Affiliation:
Department of Genetics, The University, Glasgow
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The linear relationship between fourteen allelic p-aminobenzoic-acid-requiring mutants of Aspergillus nidulans was investigated. The mutants were assigned to twelve different mutational sites within one functional region. No case of intra-cistron complementation was found. The order of sites as determined by the distribution of the outside markers in different crosses between paba alleles is consistent and the recombination fractions between the sites are approximately additive. Crossing-over between alleles is associated with strong localized negative interference. The topography of the pabal region is characterized by a marked concentration of the mutational sites in a small part of the cistron.

Type
Research Article
Information
Genetics Research , Volume 3 , Issue 1 , February 1962 , pp. 69 - 89
Copyright
Copyright © Cambridge University Press 1962

References

REFERENCES

Beadle, G. W. (1957). The role of the nucleus in heredity. The Chemical Basis of Hereditary, p. 3. Baltimore: Johns Hopkins Press.Google Scholar
Benzer, S. (1961). On the topography of the genetic fine structure. Proc. nat. Acad. Sci., Wash., 47, 403.CrossRefGoogle ScholarPubMed
Case, M. E. & Giles, N. H. (1958). Recombination mechanisms at the pan-2 locus in Neurospora crassa. Cold Spr. Harb. Symp. quant. Biol. 23, 119.CrossRefGoogle ScholarPubMed
Case, M. E. & Giles, N. H. (1960). Comparative complementation and genetic maps of the pan-2 locus in Neurospora crassa. Proc. nat. Acad. Sci., Wash., 46, 659.CrossRefGoogle ScholarPubMed
Chovnick, A. (1958). Aberrant segregation and pseudoallelism at the garnet locus in Drosophila melanogaster. Proc. nat. Acad. Sci., Wash., 44, 333.CrossRefGoogle ScholarPubMed
Crick, F. H. C., Griffith, J. S. & Orgel, L. E. (1957). Codes without commas. Proc. nat. Acad. Sci., Wash., 43, 416.CrossRefGoogle ScholarPubMed
De Serres, F. J. (1958). Recombination and interference in the ad-3 region of Neurospora crassa. Cold Spr. Harb. Symp. quant. Biol. 23, 111.CrossRefGoogle ScholarPubMed
Freese, E. (1957 a). The correlation effect for a histidine locus of Neurospora crassa. Genetics, 42, 671.CrossRefGoogle ScholarPubMed
Freese, E. (1957 b). Über die Feinstruktur des genoms im Bereich eines pab Locus von Neurospora crassa. Z. indukt. Abstamm.-u. VererbLehre, 88, 388.Google ScholarPubMed
Giles, N. H., De Serres, F. J. & Barbour, E. (1957). Studies with purple adenine mutants of Neurospora crassa. II. Tetrad analysis from a cross of an ad-3A mutant with an ad-3B mutant. Genetics, 42, 608.CrossRefGoogle Scholar
Glass, B. (1957). A Summary of the Symposium on the Chemical Basis of Heredity, p. 257. Baltimore: Johns Hopkins Press.Google Scholar
Green, M. M. (1954). Pseudo-allelism at the vermilion locus in Drosophila melanogaster. Proc. not. Acad. Sci., Wash., 40, 92.CrossRefGoogle ScholarPubMed
Green, M. M. (1955). Phenotypic variation and pseudo-allelism at the forked locus in Drosophila melanogaster. Proc. nat. Acad. Sci., Wash., 41, 375.CrossRefGoogle ScholarPubMed
Green, M. M. (1960). Double crossing-over or gene conversion at the white locus in Drosophila melanogaster. Genetics, 45, 15.CrossRefGoogle ScholarPubMed
Hexter, W. M. (1958). On the nature of the garnet locus in Drosophila melanogaster. Proc. nat. Acad. Sci., Wash., 44, 768.CrossRefGoogle ScholarPubMed
Hill, R. L. & Smith, E. L. (1956). Crystalline papain, VI. Extensive stepwise hydrolysis of mercuripapain by leucine aminopeptidase without loss of proteolytic activity. Biochim. biophys. Acta, 19, 376.CrossRefGoogle ScholarPubMed
Leupold, U. (1958). Studies on recombination in Schizosaccharomyces pombe. Cold Spr. Harb. Symp. quant. Biol. 23, 161.CrossRefGoogle ScholarPubMed
Lewis, E. B. (1945). The relation of repeats to position effect in Drosophila melanogaster. Genetics, 30, 137.CrossRefGoogle ScholarPubMed
Lindegren, C. C. (1955). Non-Mendelian segregation in a single tetrad of Saccharomyces ascribed to gene conversion. Science, 121, 605.CrossRefGoogle Scholar
Lindegren, C. C. (1961). A hypothesis concerning the mechanism of gene action. Nature, Lond., 189, 959.CrossRefGoogle ScholarPubMed
Lissouba, P. & Rizet, G. (1960). Sur l'existence d'une unité genetique polarisée ne subissent que de échanges non reciproques. C. R. Acad. Sci., Paris, 250, 3408.Google Scholar
Murray, N. E. (1960). Complementation and recombination between methionine-2 alleles in Neurospora crassa. Heredity, 15, 207.CrossRefGoogle Scholar
Mitchell, H. K. (1957). Crossing over and gene conversion in Neurospora. The Chemical Basis of Heredity, p. 94. Baltimore: Johns Hopkins Press.Google Scholar
Pontecorvo, G. (1958). Trends in Genetic Analysis. New York: Columbia University Press.Google Scholar
Pontecorvo, G., Roper, J. A., Hemmons, L. M., Macdonald, K. D. & Bufton, A. W. J. (1953). The genetics of Aspergillus nidulans. Advanc. Genet. 5, 141.CrossRefGoogle ScholarPubMed
Pontecorvo, G. & Roper, J. A. (1956). Resolving power of genetic analysis. Nature, Lond., 178, 83.CrossRefGoogle ScholarPubMed
Pontecorvo, G. & Käfer, E. (1958). Genetic analysis based on mitotic recombination. Advanc. Genet. 9, 71.CrossRefGoogle ScholarPubMed
Pritchard, R. H. (1955). The linear arrangement of a series of alleles of Aspergillus nidulans. Heredity, 9, 343.CrossRefGoogle Scholar
Pritchard, R. H. (1959). Localized negative interference and its bearing on models of gene recombination. Genet. Res. 1, 1.CrossRefGoogle Scholar
Pritchard, R. H. (1960). The bearing of recombination analysis at high resolution on fine genetic structure in Aspergillus nidulans and the mechanism of recombination in higher organisms. Microbial Genetics, p. 155. Cambridge, England.Google Scholar
Roman, H. & Jacob, F. (1958). A comparison of spontaneous and ultraviolet induced allelic recombination with reference to the recombination of outside markers. Cold Spr. Harb. Symp. quant. Biol. 23, 155.CrossRefGoogle Scholar
Roper, J. A. & Pritchard, R. H. (1955). Recovery of the complementary products of mitotic crossing-over. Nature, Lond., 179, 639.CrossRefGoogle Scholar
Siddiqi, O. H. & Putrament, A. (1961). Polarised negative interference in the paba1 region of Aspergillus nidulans. (In preparation.)Google Scholar
Strickland, W. N. (1958). Abnormal tetrads in Aspergillus nidulans. Proc. roy. Soc. B, 148, 533.Google ScholarPubMed
Sturtevant, A. H. (1925). The effect of unequal crossing-over at the bar locus in Drosophila melanogaster. Genetics, 10, 117.CrossRefGoogle Scholar