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Evidence of non-random X chromosome activity in the mouse

Published online by Cambridge University Press:  14 April 2009

B. M. Cattanach  and
C. E. Williams
B. M. Cattanach
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Berks
C. E. Williams
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Berks
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Summary

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X-linked modification of the heterozygous phenotypes of X-linked genes has been detected in the X chromosomes of several inbred strains of mice. The effect is similar to that of the alternative ‘states’ or alleles, of the X chromosome controlling element, Xce, identified in T(1; X)Ct X chromosomes. Tests on two such differing X chromosomes have indicated that the phenotypic modification results either from non-random inactivation of the two X chromosomes or from selection operating on the two cell populations differentiated by X-inactivation. The data provide evidence of non-random X chromosome activity in the somatic cells of the female mouse.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 3 , June 1972 , pp. 229 - 240
Copyright
Copyright © Cambridge University Press 1972

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