Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-25T16:31:44.488Z Has data issue: false hasContentIssue false
  • English
  • Français

Evidence of non-random X chromosome activity in the mouse

Published online by Cambridge University Press:  14 April 2009

B. M. Cattanach  and
C. E. Williams
B. M. Cattanach
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Berks
C. E. Williams
Affiliation:
MRC Radiobiology Unit, Harwell, Didcot, Berks
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

X-linked modification of the heterozygous phenotypes of X-linked genes has been detected in the X chromosomes of several inbred strains of mice. The effect is similar to that of the alternative ‘states’ or alleles, of the X chromosome controlling element, Xce, identified in T(1; X)Ct X chromosomes. Tests on two such differing X chromosomes have indicated that the phenotypic modification results either from non-random inactivation of the two X chromosomes or from selection operating on the two cell populations differentiated by X-inactivation. The data provide evidence of non-random X chromosome activity in the somatic cells of the female mouse.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 3 , June 1972 , pp. 229 - 240
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Cattanach, B. M. (1961). A chemically-induced variegated-type position effect in the mouse. Zeitscherift für Vererbungslehre 92, 165–182.Google ScholarPubMed
Cattanach, B. M. (1963). The inactive-X hypothesis and position effects in the mouse. Genetics 48, 884–885.Google Scholar
Cattanach, B. M. (1970). Controlling elements in the mouse X-chromosome. III. Influence upon both parts of an X divided by rearrangement. Genetical Research 16, 293–301.Google Scholar
Cattanach, B. M. & Isaacson, J. H. (1965). Genetic control over the inactivation of autosomal genes attached to the X-chromosome. Zeitscherift für Vererbungslehre 96, 313–323.Google ScholarPubMed
Cattanach, B. M. & Isaacson, J. H. (1967). Controlling elements in the mouse X chromosome. Genetics 57, 331–346.Google Scholar
Cattanach, B. M. & Perez, J. N. (1970). Parental influence on X-autosome translocation-induced variegation in the mouse. Genetical Research 15, 43–53.Google Scholar
Cattanach, B. M., Perez, J. N. & Pollard, C. E. (1970). Controlling elements in the mouse X-chromosome. II. Location in the linkage map. Genetical Research 15, 189–195.Google Scholar
Cattanach, B. M., Pollard, C. E. & Perez, J. N. (1969). Controlling elements in the mouse X-chromosome. I. Interaction with the X-linked genes. Genetical Research 14, 223–235.CrossRefGoogle ScholarPubMed
Dun, R. B. (1959). The development and growth of vibrissae in the house mouse with particular reference to the time of action of the Tabby (Ta) and ragged (Ra) genes. Australian Journal of Biological Science 12, 312–330.Google Scholar
Dun, R. B. & Fraser, A. S. (1959). Selection for an invariant character, vibrissa number, in the house mouse. Australian Journal of Biological Science 12, 506–523.Google Scholar
Falconer, D. S. & Isaacson, J. H. (1969). Selection for expression of a sex-linked gene (Brindled) in mice. Heredity 24, 180.Google Scholar
Giannelli, F. & Hamerton, J. L. (1971). Non-random late replication of X-chromosomes in mules and hinnies. Nature 232, 315–319.CrossRefGoogle ScholarPubMed
Grahn, D., Lea, R. A. & Hulesch, J. (1970). Linkage analysis of a presumed X-inactivation controlling element. Mouse News Letter 42, 16.Google Scholar
Gruneberg, H. (1965). Genes and genotypes affecting the teeth of the mouse. Journal of Embryology and Experimental Morphology 14, 137–159.Google Scholar
Hamerton, J. L., Richardson, B. J., Gee, P. A., Allen, W. R. & Short, R. V. (1971). Non-random X chromosome expression in female mules and hinnies. Nature 232, 312–315.Google Scholar
Hook, E. B. & Brustman, L. D. (1971). Evidence for selective differences between cells with an active horse X chromosome and cells with an active donkey X chromosome in the female mule. Nature 232, 349–350.Google Scholar
Kindred, B. M. (1961). A maternal effect on vibrissa score due to the Tabby gene. Australian Journal of Biological Science 14, 627–636.Google Scholar
Lyon, M. F. (1961). Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190, 372–373.Google Scholar
Mintz, B. (1971). Clonal basis of mammalian differentiation. In Control Mechanisms of Growth and Differentiation. Symposium of Society of Experimental Biology 25, 345–370.Google ScholarPubMed
Ohno, S. & Cattanach, B. M. (1962). Cytological study of an X-autosome translocation in Mus musculus. Cytogenetics 1, 129–140.CrossRefGoogle ScholarPubMed
Russell, L. B. (1963). Mammalian X-chromosome action: inactivation limited in spread and in region of origin. Science 140, 976–978.Google Scholar
Russell, L. B. (1971). Attempts to demonstrate different inactivating states for normal mouse X chromosomes. Genetics 68, 55–56.Google Scholar
Sofaer, J. A. (1969). Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background. Journal of Embryology and Experimental Morphology 22, 207–227.Google ScholarPubMed