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Evidence for allelism of leaner and tottering in the mouse

Published online by Cambridge University Press:  14 April 2009

Shigekatsu Tsuji  and
Hans Meier
Shigekatsu Tsuji
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine, U.S.A.
Hans Meier
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine, U.S.A.
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Summary

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We found that la is located in linkage group XVIII. It is highly probable that la and tg are alleles, and closely, linked to Es-1. Mice of the genotype la/tg are abnormal, with clinical signs similar to tg, although more severe. They develop earliest signs at about 15 days of age, similar to la, are runted but fertile and can live for months. Clinical signs are ataixa, stiffness, retarded motor activity and intermittent focal seizures. The pathological basis for these symptoms is still elusive. The three types of mice, la/la, la/tg and tg/tg are thus distinct clinically, la/tg resembling in some respect either of the other two.

Type
Research Article
Information
Genetics Research , Volume 17 , Issue 1 , February 1971 , pp. 83 - 88
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Benzer, S. (1957). The elementary units of hereditary. In The Chemical Basis of Heredity (ed. by McElroy, W. D. and Glass, H. B.), pp. 70–93. Baltimore: Johns Hopkins Press.Google Scholar
Green, M. C. (1966). Mutant genes and linkages. In Biology of the Laboratory Mouse, 2nd ed. (ed. Green, E. L.), chap. 8, pp. 87–150. New York: McGraw-Hill.Google Scholar
Green, M. C. & Sidman, R. L. (1962). Tottering, a neuromuscular mutation in the mouse and its linkage with oligosyndactylism. Journal of Heredity 53, 233–237.CrossRefGoogle Scholar
Jacob, F. & Monod, J. (1961). On the regulation of gene activity. Cold Spring Harbor Symposium on Quantitative Biology 26, 193–211.CrossRefGoogle Scholar
Meier, H. & McPike, A. D. (1970). A neurological mutation (msd) of the mouse causing a deficiency of myelin synthesis. Experimental Brain Research (in the Press).CrossRefGoogle ScholarPubMed
Pelzer, C. F. (1965). Genetic control of erythrocytic esterase forms in Mus musculus. Genetics 52, 819–828.CrossRefGoogle ScholarPubMed
Popp, R. A. & Popp, D. M. (1962). Inheritance of serum esterase having different electro-phoretic patterns among inbred strains of mice. Journal of Heredity 53, 111–114.CrossRefGoogle Scholar
Sidman, R. L., Green, M. C. & Appel, S. H. (1965). Catalog of the Neurological Mutants of the Mouse. Cambridge, Mass.: Harvard University Press.CrossRefGoogle Scholar
Tsuji, S. & Meier, H. (1969). Linkage of serum esterase and tottering in the mouse. Journal of Heredity 60, 221–222.CrossRefGoogle ScholarPubMed
Yoon, C. H. (1969). Disturbances in developmental pathways leading to a neurological disorder of genetic origin, ‘leaner’ in mice. Developmental Biology 20, 158–181.CrossRefGoogle ScholarPubMed