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Estimation of microsatellite mutation rates in Drosophila melanogaster

Published online by Cambridge University Press:  18 January 2001

JOSÉ FERNANDO VÁZQUEZ ,
TRINIDAD PÉREZ ,
JESÚS ALBORNOZ  and
ANA DOMÍNGUEZ
JOSÉ FERNANDO VÁZQUEZ
Affiliation:
Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain
TRINIDAD PÉREZ
Affiliation:
Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain
JESÚS ALBORNOZ
Affiliation:
Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain
ANA DOMÍNGUEZ
Affiliation:
Area de Genética, Departamento de Biología Funcional, Universidad de Oviedo, 33071 Oviedo, Spain

Abstract

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Microsatellite mutations were studied in a set of 175 mutation accumulation lines, all of them independently derived from a completely homozygous population of Drosophila melanogaster and maintained under strong inbreeding during 80 generations. We assayed 28 microsatellites and detected two mutations. One mutation consisted of a single addition of a dinucleotide repeat and the other was a deletion of five trinucleotide repeats. The average mutation rate was 5·1 × 10−6, in full agreement with previous estimates from two different sets of mutation accumulation lines.

Type
SHORT PAPER
Information
Genetics Research , Volume 76 , Issue 3 , December 2000 , pp. 323 - 326
Copyright
© 2000 Cambridge University Press