Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-24T08:02:22.675Z Has data issue: false hasContentIssue false
  • English
  • Français

Energy partitioning and growth in mice selected for high and low body weight

Published online by Cambridge University Press:  14 April 2009

S. K. Stephenson  and
R. C. Malik
S. K. Stephenson
Affiliation:
Department of Animal Science, University of New England, N.S.W. 2351, Australia
R. C. Malik
Affiliation:
Department of Animal Science, University of New England, N.S.W. 2351, Australia
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The partitioning of digestible energy intake on an ad libitum diet of standard mouse nuts was investigated in mice selected for high and low body weight at eight weeks and in an unselected control population. In selected mice aged from four to six weeks and housed at a temperature of 24·5 °C, almost all their energy intake could be attributed to basic maintenance and the deposition of extra protein and fat. Control mice, however, had an energy intake considerably in excess of their apparent maintenance and growth requirements. It was concluded that the unaccountable energy loss of the control line could be used to increase growth efficiency in the selected lines. The result is analogous to those obtained from studies on normal and obese mouse genotypes and indicates genetic changes in mechanisms controlling the conversion of food energy to heat.

Provision of a nest to reduce thermoregulatory heat production caused a minor reduction in energy intake and a corresponding decrease in the energy discrepancy. There was no effect on growth.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 3 , June 1984 , pp. 323 - 337
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Baker, R. L., Carter, A. H. & Cox, E. H. (1979). The effects of selection for body weight at different ages on fat deposition in mice. New Zealand Society of Animal Production 39, 118–128.Google Scholar
Barr, H. G. & McCracken, K. J. (1982). Energy balance and body composition changes in growing rats kept at 24 °C and offered a varied diet. In Energy Metabolism of Farm Animals (ed. Ekern, A. and Sundstøl, F.), pp. 160–163. EAAP Publ. no. 29.Google Scholar
Bassett, J. M. (1975). Dietary and gastro-intestinal control of hormones regulating carbohydrate metabolism in ruminants. In Digestion and Metabolism in the Ruminant (ed. McDonald, I. W. and Warner, A. C. I.), pp. 383–398. Armidale: University of New England Publishing Unit.Google Scholar
Biondini, P. E., Sutherland, T. M. & Haverland, L. H. (1968). Body composition of mice selected for rapid growth rate. Journal of Animal Science 27, 5–12.CrossRefGoogle ScholarPubMed
Corbett, J. L., Furnival, E. P. & Pickering, F. S. (1982). Energy expenditure at pasture of shorn and unshorn Bordef Leicester ewes during late pregnancy and lactation. In Energy Metabolism of Farm Animals (ed. Akern, A. and Sundstøl, F.), pp. 34–37. EAAP Publ. no. 29.Google Scholar
Dawson, N. J., Stephenson, S. K. & Fredline, D. K. (1972). Body composition of mice subjected to genetic selection for different body proportions. Comparative Biochemistry and Physiology 42 B, 679–691.Google ScholarPubMed
Falconer, D. S. (1953). Selection for large and small size in mice. Journal of Genetics 51, 470–501.CrossRefGoogle Scholar
Frisch, J. E. & Vercoe, J. E. (1981). Animal breeding for improved productivity. In Nutritional Limits to Animal Production from Pasture (ed. Hacker, J. B.). Proceedings of International Symposium (Brisbane, Aust.). Commonwealth Agricultural Bureaux.Google Scholar
Graham, N. McC., Searle, T. W. & Griffiths, D. A. (1974). Basal metabolic rate in lambs and young sheep. Australian Journal of Agricultural Research 25, 957–971.CrossRefGoogle Scholar
Hart, I. C., Bines, J. A., Morant, S. V. & Ridley, J. L. (1978). Endocrine control of energy metabolism in the cow: Comparison of the levels of hormones (prolactin, growth hormone, insulin and thyroxine) and metabolites in the plasma of high and low yielding cattle at various stages of lactation. Journal of Endocrinology 77, 333–345.CrossRefGoogle ScholarPubMed
Harvey, W. R. (1979). Users guide for LSML76: mixed model least squares and maximum likelihood computer program. Ohio State University (Mimeo.).Google Scholar
Hervey, G. R. & Tobin, G. (1983). Luxuskonsumption, diet-induced thermogenesis and brown fat: a critical review. Clinical Science 64, 7–18.CrossRefGoogle Scholar
Hayes, J. F. & McCarthy, J. C. (1976). The effects of selection at different ages for high and low body weight on the pattern of fat deposition in mice. Genetical Research 27, 389–403.CrossRefGoogle ScholarPubMed
Hetzel, D. J. S. & Nicholas, F. W. (1979). Selection of mice for growth rate under ad libitum or restricted feeding. Proceedings – Australian Association of Animal Breeding and Genetics 1, 35–36.Google Scholar
Hetzel, D. J. S. & Nicholas, F. W. (1982). Direct and correlated responses to selection for post weaning weight gain on ad libitum or restricted feeding in mice. Theoretical and Applied Genetics 63, 145–150.CrossRefGoogle ScholarPubMed
Hull, P. (1960). Genetic relations between body weight and carcass fat in mice. Journal of Agricultural Science 55, 317–321.CrossRefGoogle Scholar
James, W. P. T. & Trayhurn, P. (1981). Thermogenesis and obesity. British Medical Bulletin 37, 43–48.CrossRefGoogle ScholarPubMed
Kielanowski, J. (1976). Energy cost of protein deposition. In Protein Metabolism and Nutrition (ed. Cole, D. J. A., Boorman, K. N., Buttery, P. J., Lewis, D., Neale, R. J. and Swan, H.), pp. 207–215. EAAP Publ. no. 16.Google Scholar
Lee, V., Ranachandran, J. & Li, C. H. (1974). Does bovine growth hormone possess rapid lipolytic activity? Archives of Biochemistry and Biophysics 161, 222–226.CrossRefGoogle Scholar
Lynch, C. B. & Hegmann, J. P. (1972). Genetic differences influencing behavioural temperature regulation in small animals. I. Nesting by Mus musculus. Behavioral Genetics 2, 43–53.CrossRefGoogle ScholarPubMed
Lynch, C. B. – Possidente, B. P. (1978). Relationships of maternal nesting to thermoregulatory nesting in house mice (Mus musculus) at warm and cold temperatures. Animal Behaviour 26, 1136–1143.CrossRefGoogle Scholar
McCarthy, J. C. (1978). In Genetic Models of Obesity in Laboratory Animals. Symposium of the Medical Research Council Laboratory Animals Centre. Great Britain.Google Scholar
McPhee, C. P., Trappett, P. C., Neill, A. R. & Duncalfe, F. (1980). Changes in growth, appetite, food conversion efficiency and body composition of mice selected for high post weaning gain on restricted feeding. Theoretical and Applied Genetics 57, 49–56.CrossRefGoogle ScholarPubMed
Malik, B. C. (1984). Genetic and physiological aspects of growth, body composition and feed efficiency in mice. Ph.D. thesis, University of New England.CrossRefGoogle Scholar
Mount, L. E. (1968). The Climate Physiology of the Pig, pp. 202–211. London: Arnold.Google Scholar
Nicholls, D. G. (1979). Brown adipose tissue mitochondria. Biochimica et Biophysica Acta 549, 1–29.CrossRefGoogle ScholarPubMed
Paladini, A. C., Pena, C. & Retegui, L. A. (1979). The intriguing nature of the multiple actions of growth hormone. Trends in Biochemical Sciences 4, 256–260.CrossRefGoogle Scholar
Pullak, J. D. & Webster, A. J. F. (1977). The energy cost of protein and fat deposition in the rat. British Journal of Nutrition 37, 355–363.CrossRefGoogle Scholar
Roberts, R. C. (1979). Side effects of selection for growth in laboratory animals. Livestock Production Sciences 6, 93–104.CrossRefGoogle Scholar
Rothwell, N. J. & Stock, M. J. (1979). A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31–35.CrossRefGoogle ScholarPubMed
Rothwell, N. J. & Stock, M. J. (1981). Regulation of energy balance. Annual Review of Nutrition 1, 235–256.CrossRefGoogle ScholarPubMed
Rothwell, N. J. & Stock, M. J. (1982). Effect of chronic food restriction on energy balance, thermogenic capacity, and brown-adipose-tissue activity in the rat. Bioscience Reports 2, 543–549.CrossRefGoogle ScholarPubMed
Sutherland, T. M., Biondini, P. E. & Ward, G. M. (1974). Selection for growth rate, feed efficiency and body composition in mice. Genetics 78, 525–540.CrossRefGoogle ScholarPubMed
Trayhurn, P., Thurlby, P. L. & James, W. P. T. (1977). Thermogenic defect in pre-obese ob/ob mice. Nature 266, 60–62.CrossRefGoogle ScholarPubMed
Trayhurn, P., Jones, P. M., McGuckin, M. M. & Goodbody, A. E. (1982 a). Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice. Nature 295, 323–325.CrossRefGoogle Scholar
Trayhurn, P., Douglas, J. B. & McGuckin, M. M. (1982 b). Brown adipose tissue thermogenesis is ‘suppressed’ during lactation in mice. Nature 298, 59–60.CrossRefGoogle ScholarPubMed
Williams, V. J. & Senior, W. (1979). Changes in body composition and efficiency of food utilization for growth in young adult female rats before, during and after a period of food restriction. Australian Journal of Biological Sciences 32, 41–50.CrossRefGoogle ScholarPubMed
Wilson, P. N. & Osbourn, D. F. (1960). Compensatory growth after undernutrition in mammals and birds. Biological Reviews 35, 324–363.CrossRefGoogle ScholarPubMed
Yüksel, E., Hill, W. G. & Roberts, R. C. (1981). Selection for efficiency of feed utilisation in growing mice. Theoretical and Applied Genetics 59, 129–137.CrossRefGoogle ScholarPubMed