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Electrophoretic identity of proteins in a finite population and genetic distance between taxa

Published online by Cambridge University Press:  14 April 2009

Wen-Hsiung Li
Wen-Hsiung Li
Affiliation:
Center for Demographic and Populations Genetics, University of Texas Health Science Center, Houston, Texas 77030
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Summary

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Wehrhahn (1975) introduced the method of probability generating function to study the distribution of charge differences between homologous proteins in a population but considered only the special case where the population starts with a single allele. Some of his results, however, contained errors. In this paper, all the formulae are presented in general, correct yet much simpler forms. It is also shown that the method of diffusion equations (Ohta & Kimura, 1973) can produce the same results. Numerical computations show that the difference between the one-step and two-step models of charge changes is practically negligible. The results obtained have also been applied to study Nei's genetic distance. Numerical computations indicate that the genetic distance computed from electrophoretic data is about 10% smaller than the expected number of amino acid substitutions involving charge changes in the early stage of divergence of populations and may give a serious underestimate in comparisons between species.

Type
Research Article
Information
Genetics Research , Volume 28 , Issue 2 , October 1976 , pp. 119 - 127
Copyright
Copyright © Cambridge University Press 1976

References

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