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Effects of selection on growth, body composition and food intake in mice: II. Correlated responses in reproduction

Published online by Cambridge University Press:  14 April 2009

Forbes D. Brien ,
Gillian L. Sharp ,
William G. Hill  and
Alan Robertson
Forbes D. Brien
Affiliation:
Institute of Animal Genetics, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JN
Gillian L. Sharp
Affiliation:
Institute of Animal Genetics, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JN
William G. Hill
Affiliation:
Institute of Animal Genetics, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JN
Alan Robertson
Affiliation:
Institute of Animal Genetics, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JN
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Female reproductive performance is reported in mice selected for ten generations for one of three criteria: either appetite (A), fat percentage (F) or total lean mass (P). For each criterion lines were selected for high (H) or low (L) performance, with contemporary unselected controls (C). In the A and P lines, litter size changed in the direction of the selected criterion, the changes being larger and more rapidly established in the A than in the P lines. At generation 10, the differences in litter size between high and low lines were 2·6 live young born in the A lines, and 1·0 live young born in the P lines. The differences in 6-week weight between the high and low lines were 3·5 g in the A lines, 6·5 g in the P lines. Changes in ovulation rate were the primary reason for changes in litter size, the differences between the high and low lines being 3·8 corpora lutea for the A lines, and 3·1 corpora lutea for the P lines. Fitting body weight at mating as a covariate within lines in the analysis of ovulation rate and live foetus number removed the differences between the high and low selected P lines, but not those in the A lines. The high and low selected A and P lines did not differ in prenatal survival. There were no consistent differences in litter size, ovulation rate or pre-natal survival in the F lines.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 1 , August 1984 , pp. 73 - 85
Copyright
Copyright © Cambridge University Press 1984

References

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