Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-25T16:49:35.988Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of linkage on response to directional selection from new mutations

Published online by Cambridge University Press:  14 April 2009

P. D. Keightley  and
W. G. Hill
P. D. Keightley
Affiliation:
Institute of Animal Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
W. G. Hill
Affiliation:
Institute of Animal Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The influence of linkage on the rates of response to continued directional selection of quantitative traits deriving from variation contributed by new mutations in finite populations is investigated. Mutant genes are assumed to have additive effects which are randomly sampled from a symmetric distribution, and to be randomly located on the chromosome. Results were obtained by Monte Carlo simulation.

The expected steady rate of response, when variability from new mutations is balanced by that lost by drift and selection, is reduced the tighter the linkage, but the reduction is small unless there are few, short chromosomes. For a given rate of new mutational variance per haploid chromosome set per generation, greater effects of linkage are obtained in large than in small populations, because more mutants segregate. The response and influence of linkage are essentially the same whether the new variance is due to many genes of small effect or few of large effect.

The variability of response between replicates and generations was investigated, and the contribution to this of new mutants or recombination of existing mutants compared. Usually most genetic variability was due to the occurrence of a new favourable mutant of large effect.

Type
Research Article
Information
Genetics Research , Volume 42 , Issue 2 , October 1983 , pp. 193 - 206
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

Avery, P. J. & Hill, W. G. (1979). Variance in quantitative traits due to linked dominant genes in finite populations. Genetics 91, 817–844.CrossRefGoogle Scholar
Bulmer, M. G. (1971). The effect of selection on genetic variability. American Naturalist 105, 201–211.CrossRefGoogle Scholar
Felsenstein, J. (1965). The effect of linkage on directional selection. Genetics 52, 349–363.CrossRefGoogle ScholarPubMed
Felsenstein, J. (1974). The evolutionary advantage of recombination. Genetics 78, 737–756.CrossRefGoogle ScholarPubMed
Fisher, R. A. (1930). The Genetical Theory of Natural Selection. Oxford: Clarendon Press,CrossRefGoogle Scholar
Frankham, R. (1980). Origin of genetic variation in selection lines. In Selection Experiments in Laboratory and Domestic Animals (ed. Robertson, A.), pp. 56–68. Slough: Commonwealth Agricultural Bureaux.Google Scholar
Hill, W. G. (1982 a). Rates of change in quantitative traits from fixation of new mutations. Proceedings of the National Academy of Sciences, U.S.A. 79, 142–145.CrossRefGoogle ScholarPubMed
Hill, W. G. (1982 b). Predictions of response to artificial selection from new mutations. Genetical Research 40, 255–278.CrossRefGoogle ScholarPubMed
Hill, W. G. & Robertson, A. (1966). The effects of linkage on limits to artificial selection. Genetical Research 8, 269–294.CrossRefGoogle ScholarPubMed
Kimura, M. (1957). Some problems of stochastic processes in genetics. Annals of Mathematical Statistics 28, 882–901.CrossRefGoogle Scholar
Lande, R. (1976). The maintenance of genetic variability by mutation in a polygenic character with linked loci. Genetical Research 26, 221–235.CrossRefGoogle Scholar
Latter, B. D. H. (1966). The interaction between effective population size and selection intensity under artificial selection. Genetical Research 7, 313–323.CrossRefGoogle Scholar
Mather, K. (1941). Variation and selection of polygenic characters. Journal of Genetics 41, 159–193.CrossRefGoogle Scholar
Muller, H. J. (1964). The relation of recombination to mutational advance. Mutation Research 1, 2–9.CrossRefGoogle Scholar
Nei, M. & Murata, M. (1966). Effective population size when fertility is inherited. Genetical Research 8, 257–260.CrossRefGoogle ScholarPubMed
Robertson, A. (1970). A theory of limits in artificial selection with many linked loci. In Mathematical Topics in Population Genetics (ed. Kojima, K.), pp. 246–288. Berlin: Springer-Verlag.CrossRefGoogle Scholar
Shrimpton, A. E. (1982). The isolation of polygenic factors controlling bristle score in Drosophila melanogaster. Ph.D. Thesis, University of Edinburgh.Google Scholar
Thoday, J. M., Gibson, J. B. & Spickett, S. G. (1964). Regular responses to selection. 2. Recombination and accelerated response. Genetical Research 5, 1–19.CrossRefGoogle Scholar