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The effect of H-2 region and genetic background on hormone-induced ovulation rate, puberty, and follicular number in mice

Published online by Cambridge University Press:  14 April 2009

J. L. Spearow ,
R. P. Erickson ,
T. Edwards  and
L. Herbon
J. L. Spearow
Affiliation:
Reproductive Endocrinology Program, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA Department of Meat and Animal Science, University of Wisconsin, Madison, Wisconsin, USA
R. P. Erickson
Affiliation:
Department of Meat and Animal Science, University of Wisconsin, Madison, Wisconsin, USA
T. Edwards
Affiliation:
Reproductive Endocrinology Program, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
L. Herbon
Affiliation:
Reproductive Endocrinology Program, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
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We have examined the effects of major histocompatibility (H-2) haplotypes and genetic background (all loci other than the H-2 region) on hormone-induced ovulation rate in congenic strains of mice. In comparison with the H-2a haplotype, the H-2b haplotype increased hormone-induced ovulation rate 92% on the A/J (A) genetic background. However, H-2 haplotype did not affect hormone-induced ovulation rate on the C57BL/10J (C57) genetic background. The H-2b-linked gene(s) increased hormone-induced ovulation rate on the A/J genetic background largely by (1) enhancing the maturation of follicles in response to pregnant mare's serum gonadotrophin (PMSG) and (2) altering the stages of follicular development which can be induced to ovulate in response to human chorionic gonadotrophin (hCG). The observed effects of H-2 on hormone-induced ovulation rate were not explained by differences in the timing of puberty, the number of follicles present in untreated females, or the incidence of follicular atresia. The effect of genetic background on hormone-induced ovulation rate was much greater than was the effect of the H-2 region. We found that hormone-induced ovulation rate was five- to six-fold higher on the C57 genetic background than on the A genetic background. The C57 genetic background increased hormone-induced ovulation rate by (1) enhancing the induction of follicular maturation in response to gonadotropins and (2) by reducing the incidence of follicular atresia.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 1 , February 1991 , pp. 41 - 49
Copyright
Copyright © Cambridge University Press 1991

References

Abercrombie, M. (1946). Estimation of nuclear population from microtome sections. Anatomical Record 94, 236–247.CrossRefGoogle ScholarPubMed
Anderson, L. L. (1980). Reproductive cycles: pigs. In Reproduction in Farm Animals (ed. Hafez, E. S. E.), pp. 358–386. Philadelphia: Lea & Febiger.Google Scholar
Altman, P. L. & Katz, D. D. (1979). Inbred and Genetically Defined Strains of Laboratory Animals. Part 1: Mouse and Rat, pp. 121–130. Bethesda, Maryland: Federation of American Societies for Experimental Biology.Google Scholar
Bindon, B. M., Piper, L. R., Cummins, L. J., O'Shea, T., Hillard, M. A., Findlay, J. K. & Robertson, D. M. (1985). In Genetics of Reproduction in Sheep (ed. Land, R. B. & Robinson, D. W.), pp. 217–236. London: Butterworths.CrossRefGoogle Scholar
Cahill, L. P., Mariana, J. C. & Mauleon, P. (1979). Total follicular populations in ewes of high and low ovulation rates. Journal of Reproduction and Fertility 55, 27–36.CrossRefGoogle ScholarPubMed
Chaplin, D. D., Galbraith, L. J., Seidman, J. G., White, P. C. & Parker, K. L. (1986). Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression. Proceedings of the National Academy of Science USA 83, 9601–9605.CrossRefGoogle ScholarPubMed
Draincourt, M. A., Cahill, L. P. & Bindon, B. M. (1985). Ovarian follicular populations and preovulatory enlargement in Booroola and control Merino ewes. Journal of Reproduction and Fertility 73, 93–107.CrossRefGoogle Scholar
Due, C., Simonsen, M. & Olsson, L. (1986). The major histocompatability complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatability antigens. Proceedings of the National Academy of Science USA 83, 6007–6011.CrossRefGoogle Scholar
Fairchild, D. L. & Pate, J. L. (1989). Interferon-gamma induction of major histocompatability complex antigens on cultured bovine luteal cells. Biology of Reproduction 40, 453–457.CrossRefGoogle ScholarPubMed
Gregorova, S., Ivanyi, P., Simonova, D. & Mickova, M. (1977). H-2-Associated differences in androgen-influenced organ weights of A and C57BL/10 mouse strains and their crosses. Immunogenetics 4, 301–313.CrossRefGoogle Scholar
Hirshfield, A. N. (1985). Comparison of granulosa cell proliferation in small follicles of hypophysectomized, prepubertal and mature rats. Biology of Reproduction 32, 979–987.CrossRefGoogle ScholarPubMed
Hirshfield, A. N. (1986). Effect of a low dose of pregnant mare's serum gonadotropin on follicular recruitment and atresia in cycling rats. Biology of Reproduction 35, 113–118.CrossRefGoogle ScholarPubMed
Ivanyi, P., Gregorova, S. & Mickova, M. (1972 a). Genetic differences in thymus, lymph nodes, testes, and vesicular gland weight among inbred mouse strains. Association with the major histocompatability (H-2) system. Folia Biology 18, 81–97.Google ScholarPubMed
Ivanyi, P., Hampl, R., Starka, L. & Mickova, M. (1972 b). Genetic association between H-2 gene and testosterone metabolism in mice. Nature New Biology 238, 280–281.CrossRefGoogle ScholarPubMed
Kelly, R. W., Owens, J. L., Crosbie, S. F., McNatty, K. P. & Hudson, N. (1983). Influence of Booroola Merino genotype on the responsiveness of ewes to pregnant mare's serum gonadotropin, luteal tissue weights and peripheral progesterone concentrations. Animal Reproduction Science 6, 199–207.CrossRefGoogle Scholar
Lafuse, W., Meruelo, D. & Edidin, M. (1979). The genetic control of liver cAMP levels in mice. Immunogenetics 9, 57–65.CrossRefGoogle Scholar
Lafuse, W. & Edidin, M. (1980). Influence of the major histocompatability complex, H-2, on liver adenylate cyclase activity and on glucagon binding to liver cell membranes. Biochemistry 19, 49–54.CrossRefGoogle ScholarPubMed
Lobel, B. L., Rosenbaum, R. M. & Deane, H. W. (1961). Enzymic correlates of physiological regression of follicles and corpus lutea in ovaries of normal rats. Endocrinology 68, 232–249.CrossRefGoogle ScholarPubMed
Markovac, J. & Erickson, R. P. (1985). A component of genetic variation among mice in activity of trans-membrane methyltransferase I determined by the H-2 region. Biochemistry Pharmacology 34, 3421–3425.CrossRefGoogle Scholar
McNatty, K. P., Lun, S., Heath, D. A., Ball, K., Smith, P., Hudson, N. L., McDiarmid, J., Gibb, M. & Henderson, K. M. (1986). Differences in ovarian activity between Booroola x Merino ewes which were homozygous, heterozygous and non-carriers of a major gene influencing their ovulation rate. Journal of Reproduction and Fertility 77, 193–205.CrossRefGoogle Scholar
Pedersen, T. (1970). Follicle kinetics in the ovary of the cyclic mouse. Acta Endocrinologica 64, 304–323.Google ScholarPubMed
Pedersen, T. & Peters, H. (1968). Proposal for a classification of oocytes and follicles in the ovary of the mouse. Journal of Reproduction and Fertility 17, 555–557.CrossRefGoogle ScholarPubMed
Piper, L. R. & Bindon, B. M. (1985). The single gene inheritance of the high litter size of the Booroola Merino. In Genetics of Reproduction in Sheep (ed. Land, R. B. and Robinson, D. W.), pp. 115–125.CrossRefGoogle Scholar
Rao, M. C., Richards, J. A., Midgley, A. R. Jr & Reichert, L. E. (1977). Regulation of gonadotrophin receptors by luteinizing hormone in granulosa cells. Endocrinology 101, 512–523.CrossRefGoogle ScholarPubMed
Spearow, J. L., Erickson, R. P., Midgley, A. R., Herbon, L., Fields, S. & Malone, E. (1983). Effects of H-2 on hormone induced ovulation rate and LH receptor induction. Endocrinology 112, (Suppl. 1) 92A.Google Scholar
Spearow, J. L. (1986). Changes in the kinetics of follicular growth in response to selection for large litter size in mice. Biology of Reproduction 35, 1175–1186.CrossRefGoogle ScholarPubMed
Spearow, J. L. (1988 a). Major genes control hormone-induced ovulation rate in mice. Journal of Reproduction and Fertility 82, 787–797.CrossRefGoogle ScholarPubMed
Spearow, J. L. (1988 b). Characterization of genetic differences in hormone-induced ovulation rate of mice. Journal of Reproduction and Fertility 82, 799–806.CrossRefGoogle Scholar