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The effect of biased conversion on the mutation load

Published online by Cambridge University Press:  14 April 2009

Bengt O. Bengtsson
Bengt O. Bengtsson
Affiliation:
Department of Genetics, Lund University, Sölvegatan 29, S-223 62 Lund, Sweden
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Summary

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The mutation load is sensitive to changes in the segregation ratio caused, for example, by biased conversion. If the distortion, measured by the force of conversion, is greater than the loss of fitness in the mutation heterozygotes, then the mutation load will be far away from its normal value. Examples are given where a small positive bias together with realistic fitness parameters increase the mutation load by more than two orders of magnitude.

In practical terms this implies that great restrictions should be placed on the use of substances and treatments that may induce mutations associated with a positive conversion bias.

Type
Research Article
Information
Genetics Research , Volume 55 , Issue 3 , June 1990 , pp. 183 - 187
Copyright
Copyright © Cambridge University Press 1990

References

Bengtsson, B. O. (1985). Biased conversion as the primary function of recombination. Genetical Research 47, 77–80.Google Scholar
Bengtsson, B. O. & Uyenoyama, M. K.Evolution of the segregation ratio: Modification of gene conversion and meiotic drive. Theoretical Population Biology (in the press).Google Scholar
Charlesworth, D. & Charlesworth, B. (1987). Inbreeding depression and its evolutionary consequences. Annual Review of Ecology and Systematics 18, 237–268.Google Scholar
Crow, J. F. & Kimura, M. (1970). An Introduction to Population Genetics Theory. New York: Harper & Row.Google Scholar
Crow, J. F. & Simmons, M. J. (1983). The mutation load in Drosophila. In The Genetics and Biology of Drosophila, vol. III (ed. Ashburner, M. and Thompson, J. N.). New York: Academic Press.Google Scholar
Gutz, H. & Leslie, J. F. (1976). Gene conversion: a hitherto overlooked parameter in population genetics. Genetics 83, 861–866.CrossRefGoogle ScholarPubMed
Haldane, J. B. S. (1937). The effect of variation on fitness. American Naturalist 71, 337–349.Google Scholar
Lamb, B. C. (1984). The properties of meiotic gene conversion important in its effects on evolution. Heredity 53, 113–138.Google Scholar
Lamb, B. C. (1985). The relative importance of meiotic conversion, selection and mutation pressure, in population genetics and evolution. Genetica 67, 39–49.Google Scholar
Lamb, B.C. (1986). Gene conversion disparity: Factors influencing its direction and extent, with tests of assumptions and predictions in its evolutionary effects. Genetics 114, 611–632.Google Scholar
Lamb, B. C. & Helmi, S. (1982). The extent to which gene conversion can change allele frequencies in populations. Genetical Research 39, 199–217.Google Scholar
Muller, H. J. (1950). Our load of mutations. American Journal of Human Genetics 2, 111–176.Google Scholar
Nag, D. K., White, M. A. & Petes, T. D. (1989). Palindromic sequences in heteroduplex DNA inhibit mismatch repair in yeast. Nature 340, 318–320.CrossRefGoogle ScholarPubMed
Nagylaki, T. (1983 a). Evolution of a large population under gene conversion. Proceedings of the National Academy of Sciences, USA 80, 5941–5945.Google Scholar
Nagylaki, T. (1983 b). Evolution of a finite population under gene conversion. Proceedings of the National Academy of Sciences, USA 80, 6278–6281.Google Scholar
Ohta, T. (1989). The mutational load of a multigene family with uniform members. Genetical Research 53, 141–145.CrossRefGoogle ScholarPubMed
Sved, J. A. & Wilton, A. N. (1989). Inbreeding depression and the maintenance of deleterious genes by mutation: model of a Drosophila chromosome. Genetical Research 53, 119–128.Google Scholar
Walsh, J. B. (1983). Role of biased conversion in one-locus neutral theory and genomic evolution. Genetics 105, 461–468.CrossRefGoogle Scholar