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The effect of an unusual chromosome architecture on disjunction and non-disjunction in Drosophila

Published online by Cambridge University Press:  14 April 2009

Raphael Falk
Raphael Falk
Affiliation:
Department of Genetics, The Hebrew University, Jerusalem 91904, Israel
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Two homologous autosomes of Drosophila that were attached to form a single entire compound autosome II were found to affect the segregation of the sex chromosomes in both males and females. The compound segregated nearly always from an attached X . Y chromosome in males with no other sex chromosome. When two sex chromosomes were present together with the compound they differed in their tendency to segregate from the compound. In males the X . Y chromosome segregated more often from the compound than did the Y chromosome, and the Y chromosome segregated more often from the compound than did the regular X chromosome. In females the X . Y segregated more often from the compound than did the regular X chromosome. This preferential segregation in females was observed for exchange X chromosomes as well as for the non-exchange chromosomes.

In the presence of the compound the frequency of primary non-disjunction of the sex chromosomes was elevated in both females and males; usually both sex chromosomes segregated from the compound and only rarely with it.

Flies devoid of most of the proximal heterochromatin of the sex chromosomes die. However, when the compound autosome was present some such flies survived. This indicates that a segment of the proximal heterochromatin of the sex chromosomes was intercalated into the compound when it was constructed. It was concluded that the segment intercalated into the compound carries specific sites for sex chromosome disjunction. Specific sites determine sex chromosome disjunction in males. In females they determine the disjunction of the sex chromosomes in cooperation with exchange pairing.

Type
Research Article
Information
Genetics Research , Volume 41 , Issue 1 , February 1983 , pp. 17 - 28
Copyright
Copyright © Cambridge University Press 1983

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