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Distribution of crossing-over in mouse chromosomes

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Harwell, Oxon, 0X11 0RD, England
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In devising maps of the positions of gene loci along chromosomes, by measurements of crossing-over, it is usual to assume that the chiasmata which give rise to the crossing-over are randomly located, unless there is evidence to the contrary. If chiasmata are in fact preferentially located at certain points or regions this not only affects mapping, but also is of interest for population genetics since it may favour the development during evolution of blocks of genes relatively undisturbed by crossing-over. Preferential localization of chiasmata is well known in a number of disparate organisms (Darlington 1965; John & Lewis, 1965), but has so far been little studied in mammals. Evidence is presented suggesting tha chiasmata are in fact non-randomly located in certain chromosomes of the mouse.

Type
Research Article
Information
Genetics Research , Volume 28 , Issue 3 , December 1976 , pp. 291 - 299
Copyright
Copyright © Cambridge University Press 1976

References

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