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Digenic descent measures for finite populations*

Published online by Cambridge University Press:  14 April 2009

C. Clark Cockerham  and
B. S. Weir
C. Clark Cockerham
Affiliation:
Department of Statistics, North Carolina State University, Raleigh, North Carolina 27607
B. S. Weir
Affiliation:
Department of Statistics, North Carolina State University, Raleigh, North Carolina 27607
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Summary

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The development of a set of two-locus descent measures is reviewed. The three digenic measures, inbreeding coefficient and parental and recombinant descent coefficients, are considered in detail. The derivations of these three in pedigrees, fixed mating systems, and random mating in monoecious or dioecious populations are given. General expressions for digenic frequencies and disequilibria functions at any time are found by applying the three digenic descent measures to two types of initial populations. The final or equilibrium status of the population is also given. As the inbreeding coefficient is the same as the recombinant descent coefficient in the case of complete linkage, avoidance or promotion of early inbreeding has similar effects on the two coefficients. Estimable components of linkage disequilibrium and other measures of association within and among populations are elaborated.

Type
Research Article
Information
Genetics Research , Volume 30 , Issue 2 , October 1977 , pp. 121 - 147
Copyright
Copyright © Cambridge University Press 1977

References

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