Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-12T21:25:55.876Z Has data issue: false hasContentIssue false
  • English
  • Français

Development and complementation of lethal mutations at the dumpy locus of Drosophila melanogaster*

Published online by Cambridge University Press:  14 April 2009

Judith A. Metcalfe
Judith A. Metcalfe
Affiliation:
Department of Biology, University of York, England
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The genetical and developmental aspects of six dumpy mutants of Drosophila melanogaster have been investigated. The mutants obm, lm and olv (possibly alleles), lv, lv1 and lvI (possibly alleles) were known to be lethal when homozygous. Previously the lethal effect has been treated as a uniform effect. However, the lethal stage is not the same for all homozygotes, being egg/larval (E/L) for the three lv alleles, egg (E) for olv, larval/larval ecdysis (L/L) for lm and E/L and larval (L) for obm. Not all heterozygous combinations are lethal, i.e. obm/lm and obm/lvI are not lethal. Phenotypically the lethal heterozygotes fall into two patterns: (i) combinations not involving the allele obm and (ii) combinations involving obm. In the former, the mutant with the developmentally later expression is ‘dominant’ to the mutant with the developmentally earlier expression. In the latter, the genotypes manifest different proportions of individuals at the lethal stages E, E/L and L. Previous observations suggested that the lethality of the homozygote obm/obm was associated with the presence of an independent lethal in the stock. Observations presented here suggest that the lethality is a function of the obm allele itself. Complementation between some of the lethal mutants is not in accordance with the general rule for dumpy that compounds manifest the traits they have in common.

Type
Research Article
Information
Genetics Research , Volume 17 , Issue 3 , June 1971 , pp. 173 - 183
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Altenburg, E. & Muller, H. J. (1920). The genetic basis of truncate wing – an inconstant and modifiable character in Drosophila. Genetics 5, 1–59.CrossRefGoogle Scholar
Bodenstein, D. (1944). Induction of larval moults in Drosophila virilis. Biological Bulletin marine biology Laboratory, Woods Hole 86, 113–124.CrossRefGoogle Scholar
Carlson, E. A. (1959). Allelism, complementation and pseudoallelism at the dumpy locus in Drosophila melanogaster. Genetics 44, 347–373.CrossRefGoogle ScholarPubMed
Carlson, E. A. (1961). Limitations of geometrical models for complementation mapping of alleles. Nature 191, 788–790.CrossRefGoogle Scholar
Carlson, E. A. & Southin, J. L. (1959). Preliminary genetic evidence supporting the complementary structure of the heredity material in Drosophila spermatozoa. Genetics 44, 502–503.Google Scholar
Carlson, E. A. & Southin, J. L. (1962). Comparative mutagenesis of the dumpy locus in Drosophila melanogaster. I. X-ray treatment of mature sperm — frequency and distribution. Genetics 47, 321–336.CrossRefGoogle ScholarPubMed
Glassman, E. & Pinkerton, W. (1960). Complementation at the maroon-like eye-colour locus of Drosophila melanogaster. Science 131, 1810–1811.CrossRefGoogle ScholarPubMed
Green, M. M. (1961). Phenogenetics of the lozenge loci in Drosophila melanogaster. II. Genetics of lozenge-krivshenko (lz k). Genetics 46, 1169–1178.CrossRefGoogle Scholar
Hadorn, E. (1956). Patterns of biochemical and developmental pleiotropy. Cold Spring Harbour Symposium of quantitative Biology 21, 363–373.CrossRefGoogle ScholarPubMed
Jenkins, J. B. (1967). Mutagenesis at a complex locus in Drosophila with monofunctional alkylating agent, ethyl methanesulfonate. Genetics 57, 783–793.CrossRefGoogle Scholar
Lindsley, D. L. & Grell, E. H. (1967). Genetic variations of Drosophila melanogaster. Carnegie Institute of Washington, publ. no. 627.Google Scholar
Metcalfe, J. A. (1970). Developmental genetics of thoracic abnormalities of dumpy mutants of Drosophila melanogaster. Genetics 65, 627–654.CrossRefGoogle ScholarPubMed
Meyer, H. U. (1970). An iso-allele of the dumpy lethal. Drosophila Information Service 45, 147.Google Scholar
Novak, V. J. A. (1966). Insect Hormones. London: Methuen.Google Scholar
Oster, I. I. (1952). A study of u.v.-induced lethal mutations in Drosophila melanogaster. Heredity 6, 403–407.CrossRefGoogle Scholar
Poulson, D. F. (1940). The effects of certain X chromosome deficiencies on the embryonic development of Drosophila melanogaster. Journal of experimental Zoology 83, 271–326.CrossRefGoogle Scholar
Southin, J. L. & Carlson, B. A. (1962). Comparison of micromaps obtained by direct and indirect methods of recombination in the dumpy region of Drosophila melanogaster. Genetics 47, 1017–1026.CrossRefGoogle ScholarPubMed
Steedman, H. F. (1960). Selection Cutting in Microscopy. Oxford: Blackwell.Google Scholar
Stern, C. & Schaeffer, E. W. (1943). On wild type isoalleles in Drosophila melanogaster. Proceedings of the National Academy of Sciences U.S. 29, 361–367.CrossRefGoogle ScholarPubMed
Symmons, S. (1962). Comparative anatomy of the mallophagan head. Transactions of the Zoological Society of London 27, 349–436.CrossRefGoogle Scholar
Welshons, W. J. & Von Bialle, E. S. (1962). Pseudoallelism at the Notch locus in Drosophila. Genetics 47, 743–759.CrossRefGoogle ScholarPubMed