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The detection of shared and ancestral polymorphisms

Published online by Cambridge University Press:  06 October 2005

BRIAN CHARLESWORTH ,
CAROLINA BARTOLOMÉ  and
VÉRONIQUE NOËL
BRIAN CHARLESWORTH
Affiliation:
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh EH9 3JT, UK
CAROLINA BARTOLOMÉ
Affiliation:
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh EH9 3JT, UK Present address: Unidade de Xenética Evolutiva, Instituto de Medicina Legal, Facultade de Medicina, Universidade de Santiago de Compostela, 15782- Santiago de Compostela, Spain.
VÉRONIQUE NOËL
Affiliation:
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh EH9 3JT, UK
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Abstract

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There is increasing evidence that closely related species contain many polymorphisms that were present in their common ancestral species. Use of a more distant relative as an outgroup increases the ability to detect such ancestral polymorphisms. We describe a method for further improving estimates of the fraction of polymorphisms that are ancestral, and illustrate this with reference to data on Drosophila pseudoobscura and D. miranda. We also derive formulae for the proportion of fixations arising from ancestral polymorphisms and new mutations, respectively. The results should be useful for tests of selection based on the levels of expected and observed ancestral polymorphisms.

Type
Research Article
Information
Genetics Research , Volume 86 , Issue 2 , October 2005 , pp. 149 - 157
Copyright
© 2005 Cambridge University Press