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Dappled’ a new allele at the Mottled locus in the house mouse

Published online by Cambridge University Press:  14 April 2009

Rita J. S. Phillips
Affiliation:
Medical Research Council Radiobiological Research Unit, Harwell, Berkshire, England
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Dappled, a new completely sex-linked semi-dominant lethal mutation, is described. It is probably a new allele at the Mottled locus and has been given the symbol Modp.

Heterozygous adult females have a variegated coat very similar to that of Brindled and Mottled females; they have curly vibrissae at birth and some also have clubbed feet. All the characteristics are variable.

Hemizygous males die at about 17 days' gestation; they show a characteristic bending and thickening of the ribs and other skeletal defects. The cause of death is unknown.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1961

References

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