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Close linkage between genes which cause hairlessness in the mouse

Published online by Cambridge University Press:  14 April 2009

S. P. Flanagan  and
J. H. Isaacson
S. P. Flanagan
Affiliation:
Institute of Animal Genetics, Edinburgh 9
J. H. Isaacson
Affiliation:
Institute of Animal Genetics, Edinburgh 9
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1. A new semi-dominant gene called shaven (Sha) causes hairlessness in the mouse and it is closely linked to naked. Homozygous shaven mice never grow a first coat and adults grow a few short hairs only. Shaven heterozygotes grow a full coat which is greasy.

2. The percentage recombination between shaven and naked was found to be 0·8%. Three-point tests with naked and caracul showed that the order of the three loci is either N–Sha–Ca or N–Ca–Sha.

3. The failure of homozygous shaven mice to grow a coat is due to abnormal keratinization of the hairs in the follicles. The follicles were found to be deficient in sulphydryl groups.

4. The greasiness of the Sha+ coat is due to the presence of a sudanophilic fluid in the hair medullae.

5. The close linkage between the two genes with similar phenotypic effects is discussed.

Type
Research Article
Information
Genetics Research , Volume 9 , Issue 1 , February 1967 , pp. 99 - 110
Copyright
Copyright © Cambridge University Press 1967

References

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