Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-30T23:57:37.776Z Has data issue: false hasContentIssue false
  • English
  • Français

Chromosomal basis of dosage compensation in Drosophila: II. The DNA replication patterns of the male X-chromosome in an autosome—X insertion in D. melanogaster*

Published online by Cambridge University Press:  14 April 2009

S. C. Lakhotia
S. C. Lakhotia
Affiliation:
Cytogenetics Laboratory, Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 19, India
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The functional morphology and the replication pattern of the male X-chromosome in an autosome-X insertion stock (T(1;3) 05) of Drosophila melanogaster have been examined. In larval salivary glands carrying this insertion neither the enlargement and pale staining of the single male X, nor the characteristic early completion of replication cycle, as revealed by 3H-TdR autoradiography is in any way changed. The normal properties of the inserted autosomal segment are also unaltered. The results appear to support a ‘piecemeal’ type of dosage compensation mechanism in Drosophila operating through the male.

Type
Research Article
Information
Genetics Research , Volume 15 , Issue 3 , June 1970 , pp. 301 - 307
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Arcos-Terán, L. & Beermann, W. (1968). Changes of DNA replication behaviour associated with intragenic changes of the white region in Drosophila melanogaster. Chromosoma 25, 377–91.CrossRefGoogle ScholarPubMed
Barigozzi, C. (1968). DNA replication of eu- and heterochromatin in Drosophila. Proc. Int. Seminar on Chromosome—its Structure and Function, held in Calcutta, August 1968. The Nucleus, suppl. vol., pp. 138–44.Google Scholar
Berendes, H. D. (1966). Differential replication of male and female X-chromosomes in Drosophila. Chromosoma 20, 32–43.CrossRefGoogle Scholar
Bridges, C. B. (1935). Salivary chromosome maps. With a key to the banding of the chromosomes of Drosophila melanogaster. J. Hered. 26, 60–4.CrossRefGoogle Scholar
Cock, A. G. (1964). Dosage compensation and sex-chromatin in non-mammals. Genet. Res. 5, 354–65.CrossRefGoogle Scholar
Evans, H. J., Ford, C. E., Lyon, M. F. & Gray, J. (1965). DNA replication and genetic expression in female mice with morphologically distinguishable X-chromosomes. Nature, Lond. 206, 900–3.CrossRefGoogle ScholarPubMed
Lakhotia, S. C. & Mukherjee, A. S. (1969). Chromosomal basis of dosage compensation in Drosophila. I. Cellular autonomy of hyperactivity of the male X-chromosome in salivary glands and sex differentiation. Genet. Res. 14, 137–50.CrossRefGoogle ScholarPubMed
Lima-De-Faria, A. & Jaworska, H. (1968). Late DNA synthesis in heterochromatin. Nature, Lond. 217, 138–42.CrossRefGoogle ScholarPubMed
Lindsley, D. L. & Grell, E. H. (1968). Genetic variations of Drosophila melanogaster. Publs Carnegie Instn, no. 627.Google Scholar
Lyon, M. F. (1961). Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature, Lond. 190, 372–3.CrossRefGoogle ScholarPubMed
Mukherjee, A. S., Lakhotia, S. C. & Chatterjee, S. N. (1968). On the molecular and chromosomal basis of dosage compensation in Drosophila. Proc. Int. Seminar on Chromosome—its Structure and Function, held in Calcutta, August 1968. The Nucleus, suppl. vol., pp. 161–73.Google Scholar
Mukherjee, B. B., Ghosal, S. K., Wright, W. C., Mann, K. E. & Burkholder, G. D. (1968). Autoradiographic studies of the DNA replication pattern of mammalian sex chromosomes in somatic and germ line cells. Proc. Int. Seminar on Chromosome—its Structure and Function, held in Calcutta, August 1968. The Nucleus, suppl. vol., pp. 174–82.Google Scholar
Muller, H. J. (1950). Evidence for the precision of genetic adaptation. Harvey Lect. 43, 165–229.Google Scholar
Muller, H. J. & Kaplan, W. D. (1966). The dosage compensation in Drosophila and mammals as showing the accuracy of the normal type. Genet. Res. 8, 41–59.CrossRefGoogle ScholarPubMed
Nash, D. & Bell, J. (1968). Larval age and the pattern of DNA synthesis in polytene chromosomes. Can. J. Genet. Cytol. 10, 82–90.CrossRefGoogle ScholarPubMed
Ohno, S. & Cattanach, B. M. (1962). Cytological study of an X-autosome translocation in Mus musculus. Cytogenetics 1, 129–40.CrossRefGoogle ScholarPubMed
Rodman, T. C. (1968). Relationship of developmental stage to initiation of replication in polytene nuclei. Chromosoma 23, 271–87.CrossRefGoogle ScholarPubMed
Russell, L. B. (1961). Genetics of mammalian sex chromosomes. Science, N. Y. 133, 1795–1803.CrossRefGoogle ScholarPubMed
Russell, L. B. (1963). Mammalian X-chromosome action: inactivation limited in spread and in region of origin. Science, N.Y. 140, 976–8.CrossRefGoogle ScholarPubMed
Russell, L. B. & Montgomery, C. S. (1965). The use of X-autosome translocation in locating the X-chromosome inactivation center. Genetics, Princeton 52, 470–1 (abstr.).Google Scholar
Schultz, J. (1965). Genes, differentiation and animal development. Brookhaven Symp. Biol. 18, 116–47.Google ScholarPubMed