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Chromosomal anomalies that cause male sterility in the mouse also reduce ovary size

Published online by Cambridge University Press:  14 April 2009

Ursula Mittwoch ,
Shantha Mahadevaiah  and
Leslie A. Setterfield
Ursula Mittwoch
Affiliation:
Department of Genetics and Biometry, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE
Shantha Mahadevaiah
Affiliation:
Department of Genetics and Biometry, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE
Leslie A. Setterfield
Affiliation:
Department of Genetics and Biometry, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE
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Summary

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Two male-sterile chromosome anomalies, the insertion Is(7; 1)40H and the tertiary trisomy, Ts(512)31H, were found to be associated with reduced ovarian volumes in immature females. Together with the reciprocal translocation, T(11; 19)42H, in which this effect was described previously, reduced ovaries have been found in all three male-sterile chromosome anomalies investigated so far, suggesting that ovarian involvement is likely to be common in these conditions. Assuming that the smaller ovarian size reflects a reduction in the number of oocytes, it is suggested that male-sterile chromosome anomalies may exert basically similar deleterious effects on meiotic germ cells in males and females, the difference in outcome being due to cell-physiological differences between spermatocytes and oocytes and to the small number of surviving oocytes required for fertility in females.

Type
Short Paper
Information
Genetics Research , Volume 44 , Issue 2 , October 1984 , pp. 219 - 224
Copyright
Copyright © Cambridge University Press 1984

References

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