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Cellular autonomy of hyperactivity in segmental X chromosomal aneuploids of Drosophila and dosage compensation

Published online by Cambridge University Press:  14 April 2009

Jayashree Prasad-Sinha  and
A. S. Mukherjee
Jayashree Prasad-Sinha
Affiliation:
Genetics Research Unit, Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700 019, India
A. S. Mukherjee
Affiliation:
Genetics Research Unit, Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700 019, India
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Transcription in 9A–11A aneuploid mosaic female larvae of Drosophila melanogaster has been assessed autoradiographically. Eleven larvae were found to exhibit mosaicism out of sixty-six larvae scanned and the percentage of XO and XX nuclei varied from approximately 9 to 100. Irrespective of the number of XX nuclei present the XO nuclei (duplicated for 9A–11A) invariably showed hyperactivity for both the segments. The XX nucleus exhibited a dosage effect for all the three segments of 9A–11A. Results support the transcriptional constancy of the entire X chromosome, as proposed by Maroni and Lucchesi. Cellular autonomy of hyperactivity of the single X chromosome even at the level of segments of the X is thus evident from the present results.

Type
Research Article
Information
Genetics Research , Volume 46 , Issue 1 , August 1985 , pp. 19 - 29
Copyright
Copyright © Cambridge University Press 1985

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