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Cattanach's translocation [Is(7:X)Ct] corrects male sterility due to homozygosity for chromosome 7 deletions

Published online by Cambridge University Press:  14 April 2009

Robert P. Erickson
Robert P. Erickson
Affiliation:
Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI
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Summary

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Mice carrying particular deletions of chromosomal material at and around the colour (C) locus on chromosome 7 (c3H/c6H) are viable but sterile. An insertional translocation of chromosome 7 into the X (Cattanach's) has been previously used to rescue females carrying deletions of chromosome 7 which are ordinarily lethal. We studied the ability of this translocation to correct the sterility found in the presence of the two partially complementing deletions. We predicted that the sterility would be corrected in females who would be mosaics because of X-inactivation. The result in males was uncertain since the sterility had been shown to be due to defective spermatogenesis, and the X chromosome is inactivated early in the course of spermatogenesis. The c3H/c6H male and female deletional sterility were rescued by Cattanach's translocation.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 1 , February 1984 , pp. 35 - 41
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Baier, L., Hanash, S. & Erickson, R. P. (1983). Mice homozygous for chromosomal deletions at the albino locus region lack specific polypeptides in two-dimensional gels. Proceedings of the National Academy of Sciences USA. (In the Press.)Google Scholar
Cattanach, B. M. & Isaacson, J. H. (1965). Genetic control over the inactivation or autosomal genes attached to the X-chromosome. Zeitschrift für Vererbungslehre 96, 313–323.Google ScholarPubMed
Eicher, E. M. (1967). The genetic extent of the insertion involved in the flecked translocation in the mouse. Genetics 55, 203–212.CrossRefGoogle ScholarPubMed
Eicher, M. & Kirkland, J. (1969). Unpublished data, cited in Eicher, E. M. (1970). X-autosome translocations in the mouse: total inactivation versus partial inactivation of the X chromosome. Advances in Genetics 15, 175–259.CrossRefGoogle Scholar
Erickson, R. P. (1975). Mouse spermatozoal glucose-6-phosphate dehydrogenase is the X-linked form. Biochemical and Biophysical Research Communications 63, 1000–1004.CrossRefGoogle ScholarPubMed
Erickson, R. P. (1976). Glucose-6-phosphate dehydrogenase activity changes during spermato-genesis: possible relevance to X-chromosome inactivation. Developmental Biology 53, 134–137.CrossRefGoogle Scholar
Erickson, R. P., Lewis, S. & Butley, M. (1981). Is haploid gene expression possible for sperm antigens? Journal of Reproductive Immunology 3, 195–217.CrossRefGoogle ScholarPubMed
Fujimoto, H., Erickson, R. P., Quinto, M. & Rosenberg, M. (1983). Molecular cloning of mRNA sequences transcribed post-meiotically during spermatogenesis in mice. (In preparation.)Google Scholar
Geyer-Duszỳnska, I. (1963). On the structure of the XY bivalent in Mus musculus L. Chromosoma (Berl.) 13, 521–525.CrossRefGoogle ScholarPubMed
Gluecksohn-Waelsch, S. (1979). Genetic control of morphogenetic and biochemical differentiation: lethal albino deletions in the mouse. Cell 16, 225–237.CrossRefGoogle ScholarPubMed
Gluecksohn-Waelsch, S., Teicher, L. S., Pick, L. & Cori, C. F. (1980). Genetic rescue of lethal genotypes in the mouse. Development Genetics 1, 219–228.CrossRefGoogle Scholar
Hotta, Y. & Chandley, A. C. (1982). Activities of X-linked enzymes in spermatocytes of mice rendered sterile by chromosomal alterations. Gamete Research 6, 65–72.CrossRefGoogle Scholar
Kierszenbaum, A. L. & Tres, L. L. (1974). Nucleolar and perichromosomal RNA synthesis during meiotic prophase in the mouse testis. Journal of Cell Biology 60, 39–53.CrossRefGoogle ScholarPubMed
Kierszenbaum, A. L. & Tres, L. L. (1975). Structural and transcriptional features of the mouse spermatid genome. Journal of Cell Biology 65, 258–270.CrossRefGoogle ScholarPubMed
Kofman-Alfaro, S. & Chandley, A. C. (1970). Meiosis in the male mouse. An autoradiographic investigation. Chromosoma (Berl.) 31, 404–420.CrossRefGoogle ScholarPubMed
Kramer, J. M. & Erickson, R. P. (1981). Developmental program of PGK-1 and PGK-2 isozymes in spermatogenic cells of the mouse: specific activities and rates of synthesis. Developmental Biology 87, 31–45.Google ScholarPubMed
Kratzer, P. G., Chapman, V. M., Lambert, H., Evans, R. E. & Liskay, R. M. (1983). Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of mice. Cell 33, 37–42.CrossRefGoogle ScholarPubMed
Lewis, S. E., Turchin, H. A. & Wojtowicz, T. E. (1978). Fertility studies of complementing genotypes at the albino locus of the mouse. Journal of Reproduction & Fertility 53, 197–202.CrossRefGoogle ScholarPubMed
Lifschytz, E. (1972). X-chromosome inactivation: an essential feature of normal spermiogenesis in male heterogametic organisms. In Proceedings, International Symposium on The Genetics of the Spermatozoon (eds. Beatty, R. A. & Gluecksohn-Waelsch, S.), pp. 223–232. Edinburgh and New York: privately published.Google Scholar
Monesi, V. (1965). Differential rate of ribonucleic acid synthesis in the autosomes and sex chromosomes during male meiosis in the mouse. Chromosoma (Berl.) 17, 11–21.CrossRefGoogle ScholarPubMed
Moses, M. J., Counce, S. J. & Paulson, D. F. (1975). Synaptonemal complex complement of man in spreads of spermatocytes, with details of the sex chromosome pair. Science 187, 363–365.CrossRefGoogle ScholarPubMed
Odartchenko, N. & Pavillard, M. (1970). Late DNA replication in male mouse meiotic chromosomes. Science 167, 1133–1134.CrossRefGoogle ScholarPubMed
Ohno, S., Jainchill, J. & Stenius, C. (1963). The creeping vole (Microtus oregoni) as a gonosomic mosaic. I. The OY/XY constitution of the male. Cytogenetics 2, 232–239.CrossRefGoogle ScholarPubMed
Ohno, S., Kaplan, W. D. & Kinosita, R. (1959). On the end-to-end association of the X and Y chromosomes of Mus musculus. Experimental Cell Research 18, 282–290.CrossRefGoogle ScholarPubMed
Sachs, L. (1954). Sex-linkage and the sex chromosomes in man. Annals of Eugenics 18, 255–261.Google ScholarPubMed
Solari, A. J. & Tres, L. L. (1970). The three-dimensional reconstruction of the XY chromosomal pair in human spermatocytes. Journal of Cell Biology 45, 45–53.Google ScholarPubMed
Takagi, N. & Sasaki, M. (1975). Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse. Nature (Lond.) 256, 640–642.CrossRefGoogle ScholarPubMed
Tres, L. L. (1975). Nucleolar RNA synthesis of meiotic prophase spermatocytes in the human testes. Chromosoma (Berl.) 53, 141–151.CrossRefGoogle Scholar
West, J. D., Frels, W. I., Chapman, V. M. & Papaicannou, V. E. (1977). Expression of the maternally derived X chromosome in the mouse yolk sac. Cell 12, 873–882.CrossRefGoogle ScholarPubMed