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The basis for an apparent auxotrophy for reduced sulphur metabolites in sF mutants of Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

Herbert N. Arst Jr
Affiliation:
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, England
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sF mutants of Aspergillus nidulans are subject to toxicity by a metabolite derived from sulphate but are not blocked in cysteine biosynthesis. Bearing in mind the unavoidable presence of sulphate in agar-solidified media, their apparent auxotrophy for thiosulphate, L-cysteine or L-methionine stems from the ability of these reduced sulphur-containing metabolites to repress, directly or indirectly, the syntheses of sulphate permease and the enzymes of sulphate assimilation, thereby preventing synthesis of the toxic metabolite.

Type
Short paper
Copyright
Copyright © Cambridge University Press 1977

References

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