Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-28T07:49:53.517Z Has data issue: false hasContentIssue false
  • English
  • Français

Bare-patches, a new sex-linked gene in the mouse, associated with a high production of XO females: I. A preliminary report of breeding experiments*

Published online by Cambridge University Press:  14 April 2009

Rita J. S. Phillips ,
S. G. Hawker  and
H. J. Moseley
Rita J. S. Phillips
Affiliation:
Medical Research Council Radiobiology Unit, Harwell, Didcot, Berks. OX11 ORD
S. G. Hawker
Affiliation:
Medical Research Council Radiobiology Unit, Harwell, Didcot, Berks. OX11 ORD
H. J. Moseley
Affiliation:
Medical Research Council Radiobiology Unit, Harwell, Didcot, Berks. OX11 ORD
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Bare-patches (Bpa), a semi-dominant, sex-linked, male-lethal gene in the mouse is described. It shows 14·5 ± 3·0% recombination with Blo and 5·4 ± 2·2 % with Ta and may, therefore, be allelic with Str.

Only about half the expected number of heterozygous females is observed; the remainder appear to lose their mutant chromosome and become XO females as there is an excess of non-Bpa females, at least 24% of which proved to be XO. It is not yet certain whether the lost X chromosome is always the mutant one nor is it certain whether the loss is a property of the Bpa gene or due to a closely linked factor: a separate factor seems more likely. Some possible mechanisms for XO production are discussed.

Type
Research Article
Information
Genetics Research , Volume 22 , Issue 1 , August 1973 , pp. 91 - 99
Copyright
Copyright © Cambridge University Press 1973

References

REFERENCES

Barber, B. R. (1971). Harlequin. Mouse News Letter 45, 35.Google Scholar
Bianchi, N. O. & Contreras, J. R. (1967). The chromosomes of the field mouse Akodon azarae (Cricetidae, Rodentia) with special reference to sex chromosome anomalies. Cytogenetics 6, 306–313.CrossRefGoogle ScholarPubMed
Cattanach, B. M. (1962). XO mice. Genetical Research 3, 487–490.CrossRefGoogle Scholar
Falconer, D. S. & Isaacson, J. H. (1972). Harlequin and brindled-linkage, and difference between coupling and repulsion phenotypes. Mouse News Letter 47, 28.Google Scholar
Fredga, K. (1964). A simple technique for demonstration of the chromosomes and mitotic stages in a mammal. Chromosomes from the Cornea. Hereditas (Lund) 51, 268–273.CrossRefGoogle Scholar
Lyon, M. F. (1961). Gene action in the X-chromosome of the mouse. Nature, London 190, 372–373.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1963). Attempts to test the inactive-X theory of dosage compensation in mammals. Genetical Research 4, 93–103.CrossRefGoogle Scholar
Lyon, M. F., Phillips, R. J. S. & Bailey, H. J. (1972). Mutagenic effects of repeated small radiation doses to mouse spermatogonia. 1. Specific locus mutation rates. Mutation Research 15, 185–190.CrossRefGoogle Scholar
Lyon, M. F., Searle, A. G., Ford, C. E. & Ohno, S. (1964). A mouse translocation suppressing sex-linked variegation. Cytogenetics 3, 306–323.CrossRefGoogle ScholarPubMed
Morris, T. (1968). XO and OY chromosome constitutions in the mouse. Genetical Research 12, 125–137.CrossRefGoogle ScholarPubMed
Ohno, S. (1963). Life history of female germ cells in mammals. 2nd International Conference on Congenital Malformations, pp. 30–42. New York: International Medical Congress Ltd.Google Scholar
Phillips, R. J. S. (1963). Striated, a new sex-linked gene in the house mouse. Genetical Research 4, 151–153.CrossRefGoogle Scholar
Russell, L. B. (1966). Radiation-induced sex-chromosome abnormalities in female germ cell stages of the mouse. Abstract for 35th Annual Meeting of the Genetic Society of America at Chicago, Illinois (1–3 Sept.).Google Scholar
Yong, Hoi Sen (1971). Presumptive X monosomy in black rats from Malaya. Nature, London 232, 484–485.Google Scholar