Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-28T00:33:03.104Z Has data issue: false hasContentIssue false
  • English
  • Français

Bacteriophage T4 resistance to lysis-inhibition collapse

Published online by Cambridge University Press:  01 August 1999

STEPHEN T. ABEDON
STEPHEN T. ABEDON
Affiliation:
Department of Microbiology, The Ohio State University, 1680 University Drive, Mansfield, OH 44906, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Lysis inhibition is a mechanism of latent-period extension and burst-size increase that is induced by the T4 bacteriophage adsorption of T4-infected cells. Mutants of T4 genes imm, sp and 5 (specifically the ts1 mutant of 5) display some lysis inhibition. However, these mutants experience lysis-inhibition collapse, the lysis of lysis-inhibited cells, earlier than wild-type-infected cells (i.e. their collapse occurs prematurely). Lysis from without is a lysis induced by excessive T4 adsorption. Gp5 is an inducer of lysis from without while gpimm and gpsp effect resistance to lysis from without. This paper shows that interfering with the adsorption of phages to imm-, sp- or 5ts1-mutant-infected cells, in a variety of contexts, inhibits premature lysis-inhibition collapse. From these data it is inferred that wild-type T4-infected cells display resistance to lysis-inhibition collapse by a mechanism resembling resistance to lysis from without.

Type
Research Article
Information
Genetics Research , Volume 74 , Issue 1 , August 1999 , pp. 1 - 11
Copyright
© 1999 Cambridge University Press