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Analysis of the genetic instability induced by nitrous acid in Schizosaccharomyces pombe

Published online by Cambridge University Press:  14 April 2009

N. Loprieno ,
A. Abbondandolo ,
S. Bonatti  and
R. Guglielminetti
N. Loprieno
Affiliation:
Institute of Genetics, The University, Pisa, Italy
A. Abbondandolo
Affiliation:
Institute of Genetics, The University, Pisa, Italy
S. Bonatti
Affiliation:
Institute of Genetics, The University, Pisa, Italy
R. Guglielminetti
Affiliation:
Institute of Genetics, The University, Pisa, Italy
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A pedigree analysis of several cell-colony generations following a mutagenic treatment with nitrous acid has shown that in S. pombe a genetic instability is produced that replicates several times and produces a mutation in independent lines.

It has been shown that the mutants isolated in the progeny of a mosaic colony all contain a genetic alteration that cannot be resolved by genetic analysis and therefore the mutations have occurred at the same genetic site. This finding is confirmed by interallelic complementation and phenotypic analyses.

Type
Research Article
Information
Genetics Research , Volume 12 , Issue 1 , August 1968 , pp. 45 - 54
Copyright
Copyright © Cambridge University Press 1968

References

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