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Age-related reactivation of an X-linked gene close to the inactivation centre in the mouse

Published online by Cambridge University Press:  14 April 2009

Sheila Brown  and
Sohaila Rastan
Sheila Brown
Affiliation:
Division of Comparative Medicine, Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ
Sohaila Rastan*
Affiliation:
Division of Comparative Medicine, Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ
*
* Corresponding author.
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Summary

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Age-related reactivation of an X-linked gene which maps close to Xce, the X chromosome inactivation centre, has been observed. In five female mice which carried the X-linked coat colour gene Moblo on the reciprocal translocation T(X;16)16H (Searle's translocation), and the wild-type gene on the normal X chromosome, and therefore expressed the Moblo phenotype due to the non-random inactivation characteristic of Searle's translocation, progressive darkening of the coat was observed as the animals aged. This is due to reactivation of the previously inactivated wild-type gene at the Mo locus on the normal X chromosome. As the Mo locus is located 4 cM distal to Xce, the X chromosome inactivation centre, these observations provide evidence of age-related instability of inactivation of an X-linked gene close to the inactivation centre.

Type
Research Article
Information
Genetics Research , Volume 52 , Issue 2 , October 1988 , pp. 151 - 154
Copyright
Copyright © Cambridge University Press 1988

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