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Actual number of alleles contained in a multigene family

Published online by Cambridge University Press:  14 April 2009

Tomoko Ohta
Affiliation:
National Institute of Genetics, Mishima, 411, Japan
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Summary

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By using a simple model of gene conversion, the actual number of alleles contained in a multigene family was theoretically studied. It was shown that the Ewens' sampling theory is applicable to predict the actual number in a gene family of a genome. However, the actual number of the gene family forming the total population becomes larger or smaller than the predicted value by the sampling theory, depending upon the relative magnitude of the rates of two homogenization processes, i.e. intra-genome and in the population.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1986

References

Arnheim, N., Treco, D., Taylor, B. & Eicher, E. (1982). Distribution of ribosomal gene length variants among mouse chromosomes. Proceedings of the National Academy of Sciences, USA 79, 46774680.CrossRefGoogle ScholarPubMed
Coen, E. S., Thoday, J. M. & Dover, G. (1982). Rate of turnover of structural variants in the rDNA gene family of Drosophila melanogaster. Nature 295, 564568.Google Scholar
Ewens, W. J. (1972). The sampling theory of selectively neutral alleles. Theoretical Population Biology 3, 87112.Google Scholar
Gojobori, T. & Nei, M. (1986). Relative contributions of germ-line gene variation and somatic mutation to immunoglobulin diversity. Molecular Biology and Evolution 3, 156167.Google Scholar
Kabat, E. A., Wu, T. T. & Bilofsky, H. (1976). Variable Regions of Immunoglobulin Chains. Cambridge, Mass.: Medical Computer Systems, Bolt, Beranek and Newman.Google Scholar
Kimura, M. & Crow, J. F. (1964). The number of alleles that can be maintained in a finite population. Genetics 49, 725738.Google Scholar
Kimura, M. & Ohta, T. (1975). Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proceedings of the National Academy of Sciences, USA 72, 27612764.Google Scholar
Nagylaki, T. (1984 a). The evolution of multigene families under intrachromosomal gene conversion. Genetics 106, 529548.Google Scholar
Nagylaki, T. (1984 b). Evolution of multigene families under interchromosomal gene conversion. Proceedings of the National Academy of Sciences, USA 81, 37963800.Google Scholar
Nagylaki, T. & Barton, N. (1985). Intrachromosomal gene conversion, linkage, and the evolution of multigene families. Theoretical Population Biology (In the Press.)Google Scholar
Ohta, T. (1980). Evolution and Variation of Multigene Families. Lecture Notes in Biomathematics, vol. 37. Berlin, New York: Springer-Verlag.Google Scholar
Ohta, T. (1982). Allelic and nonallelic homology of a supergene family. Proceedings of the National Academy of Sciences, USA 79, 32513254.Google Scholar
Ohta, T. (1983 a). On the evolution of multigene families. Theoretical Population Biology 23, 216240.Google Scholar
Ohta, T. (1983 b). Time until fixation of a mutant belonging to a multigene family. Genetical Research 41, 4755.Google Scholar
Ohta, T. (1984). Population genetics theory of concerted evolution and its application to the immunoglobulin V gene tree. Journal of Molecular Evolution 20, 274280.Google Scholar
Ohta, T. & Dover, G. (1984). The cohesive population genetics of molecular drive. Genetics 108, 501521.Google Scholar
Ohta, T. & Kimura, M. (1973). A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genetical Research 22, 201204.Google Scholar
Wellauer, P. K., Reeder, R. H., Dawid, I. B. & Brown, D. D. (1976). The arrangement of length heterogeneity in repeating units of amplified and chromosomal ribosomal DNA from Xenopus leavis. Journal of Molecular Biology 105, 487505.Google Scholar
Williams, S. M., DeSalle, R. & Strobeck, C. (1985). Homogenization of geographical variants at the nontranscribed spacer of rDNA in Drosophila mercatorum. Molecular Biology and Evolution 2, 338346.Google Scholar
Williams, S. M. & Strobeck, C. (1985). Sister chromatid exchange and the evolution of rDNA spacer length. Journal of Theoretical Biology 116, 625636.Google Scholar