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Absence of mitochondrial malic enzyme in mice carrying two complementing lethal albino alleles

Published online by Cambridge University Press:  14 April 2009

Eva M. Eicher ,
Susan E. Lewis ,
Howard A. Turchin  and
Salome Gluecksohn-Waelsch
Eva M. Eicher
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609
Susan E. Lewis
Affiliation:
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
Howard A. Turchin
Affiliation:
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
Salome Gluecksohn-Waelsch
Affiliation:
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
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Mitochondrial malic enzyme (MOD-2) was found to be missing in partially complementing genotypes between lethal deletion alleles at the albino locus in Chromosome 7 of the mouse. Since such partial complementers survive to adulthood, the absence of normal mitochondrial malic enzyme is compatible with life; however, the sterility of both females and males may be correlated with this enzyme deficiency. Of the six radiation-induced lethal albino mutations, five includedeletions for the Mod-2 locus mapping 1 centimorgan distally from c. Our data indicate that the maximum genetic distance occupied by any of these deletions is 6 centimorgans.

Type
Research Article
Information
Genetics Research , Volume 32 , Issue 1 , August 1978 , pp. 1 - 7
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Eicher, E. M. (1977). Murine ovarian teratomas and parthenotes as cytogenetic tools. Cytogenelics and Cell Genetics (in the Press).Google Scholar
Eicher, E. M. & Coleman, D. L. (1977). Influence of gene duplication and X-inactivation on mouse mitochondrial malic enzyme activity and electrophoretic patterns. Genetics 85, 647–638.CrossRefGoogle ScholarPubMed
Erickson, R. P., Eicher, E. M. & Gluecksohn-Waelsch, S. (1974). Demonstration in the mouse of X-ray induced deletions for a known enzyme structural locus. Nature 248, 416–418.CrossRefGoogle Scholar
Erickson, R. P., Gluecksohn-Waelsch, S. & Cori, C. F. (1968). Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proceedings of the National Academy of Sciences, U.S.A. 59, 437–444.CrossRefGoogle ScholarPubMed
Garland, R. C., Satrustegui, J., Gluecksohn-Waelsch, S. & Cori, C. F. (1976). Deficiency of plasma protein synthesis caused by X-ray induced lethal albino alleles in mouse. Proceedings of the National Academy of Sciences, U.S.A. 73, 3376–3380.CrossRefGoogle Scholar
Gluecksohn-Waelsch, S. & Cori, C. F. (1970). Glucose-6-phosphatase deficiency: Mechanisms of genetic control and biochemistry. Biochemical Genetics 4, 195–201.CrossRefGoogle ScholarPubMed
Gluecksohn-Waelsch, S., Schiffman, M. B., Thorndike, J. & Cori, C. F. (1974). Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase and serine dehydratase. Proceedings of the National Academy of Sciences, U.S.A. 71, 825–829.CrossRefGoogle ScholarPubMed
Green, M. C. (1975). Linkage map of the mouse. Mouse News Letter 53, 10.Google Scholar
Harris, H. (1975). The Principles of Human Biochemical Genetics, pp. 78–84. 2nd ed.Amsterdam, Oxford: North-Holland.Google Scholar
Jagiello, G., Fang, J. S., Turchin, H. A., Lewis, S. E. & Gluecksohn-Waelsch, S. (1976). Cytological observations of deletions in pachytene stages of oogenesis and spermatogenesis in the mouse. Chromosoma 58, 377–386.CrossRefGoogle ScholarPubMed
Lewis, S. E. (1978). Developmental analysis of lethal effects of homozygosity for the c25H deletion in the mouse. Developmental Biology (in the Press).CrossRefGoogle Scholar
Lewis, S. E., Gluecksohn-Waelsch, S. & Turchin, H. A. (1976). The developmental analysis of an embryonic lethal (c6H) in the mouse. Journal of Embryology and Experimental Morphology 36, 363–371.Google ScholarPubMed
Miller, D. A., Dev, V. G., Tantravahi, R., Miller, O. J., Schiffman, M. B., Yates, R. A. & Gluecksohn-Waelsch, S. (1974). Cytological detection of the c25H deletion involving the albino (c) locus on Chromosome 7 in the mouse. Genetics 78, 905–910.CrossRefGoogle Scholar
Thorndike, J., Trigg, M. J., Stockert, R., Gluecksohn-Waelsch, S. & Cori, C. F. (1973). Multiple biochemical effects of a series of alleles in the mouse. Biochemical Genetics 9, 25–39.CrossRefGoogle Scholar
Trigg, M. J. & Gluecksohn-Waelsch, S. (1973). Ultrastructural basis of biochemical effects in a series of lethal alleles in the mouse. Journal of Cell Biology 58, 549–563.CrossRefGoogle Scholar