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Hypoxic-ischaemic injury of the neonatal brain

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  15 January 2010

JS Wyatt
JS Wyatt*
Affiliation:
University College London Medical School, London WC1E 6JJ
*
Department of Paediatrics, University College London Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ
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Extract

Despite advances in obstetric and neonatal care, hypoxia-ischaemia remains as probably the commonest cause of severe disabling brain injury which occurs in the perinatal period. Although for the population as a whole, congenital brain abnormality and early fetal events are the most frequent antecedent of permanent neurodevelopmental disability, perinatal brain injury is an important and potentially preventable cause of severe and permanent handicap in both developed and developing countries.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 8 , Issue 2 , May 1996 , pp. 95 - 108
Copyright
Copyright © Cambridge University Press 1996

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References

1Levene, MI. The asphyxiated newborn infant. In: Levene, MI, Lilford, RJ eds, Fetal and Neonatal Neurology and Neurosurgery. Edinburgh: Churchill Livingstone, 1995: 405–25.Google Scholar
2Brown, JK, Purvis, RJ, Forfar, JO, Cockburn, F. Neurological aspects of perinatal asphyxia. Dev Med Child Neurol 1974; 16: 567–80.CrossRefGoogle ScholarPubMed
3Levene, MI, Kornberg, J, Williams, THC. The incidence and severity of post asphyxiai encephalopathy in the severely asphyxiated newborn. Arch Dis Child 1985; 58: 1013–1015.CrossRefGoogle Scholar
4De Vries, LS, Levene, MI. Cerebral ischaemic lesions. In: Levene, MI, Lilford, RJ, eds, Fetal and Neonatal Neurology and Neurosurgery Edinburgh: Churchill Livingstone, 1995; 367–86.Google Scholar
5Gaffney, G, Flavell, F, Johnson, A, Squier, M, Sellers, S. Cerebral palsy and neonatal encephalopathy. Arch Dis Child 1994; 70: F195–F200.CrossRefGoogle ScholarPubMed
6Nelson, KB, Ellenberg, JH. Antecedents of cerebral palsy: multivariant analysis of risk. N Engl J Med 1986; 315 81–86.Google Scholar
7Blair, E, Stanley, SJ. Intrapartum asphyxia: a rare cause of cerebral palsy. J Pediatr 1988; 112: 515–19.Google Scholar
8Barkovich, J. Formation, maturation and disorders of brain neocortex. AJNR 1992; 13: 423–46.Google ScholarPubMed
9Wicklund, LM, Uvebrandt, P, Flodmark, O. Morphology of cerebral lesions in children with congenital hemiplegia: a study with computed tomography. Neuroradiology 1990; 31: 179–86.Google Scholar
10Flodmark, O. Imaging of the neonatal brain. In: Levene, MI, Lilford, RJ, eds, Fetal and Neonatal Neurology and Neurosurgery Edinburgh: Churchill Livingstone, 1995; 367–86.Google Scholar
11Squier, MV, Keeling, JW. The incidence of prenatal brain injury. Neuropathol Appi Neurobiol 1991; 17: 29–38.Google Scholar
12Volpe, JJ, Pasternak, JF. Parasagittal cerebral injury in neonatal hypoxic-ischaemic encephalopathy: clinical and neuroradiologic features. J Pediatr 1977; 91: 472–76.CrossRefGoogle ScholarPubMed
13Barth, PG, Valk, J, Olislagers-de Siegte, R. Aspect scanographique des zones corticales et sous-corticales dans les paralysies cerebrales. J Neuroradiol 1984; 11: 65–71.Google Scholar
14Nelson, KB, Ellenberg, JH. Apgar scores as predictors of chronic neurological disability. Pediatrics 1981; 68: 36–44.CrossRefGoogle Scholar
15Dennis, J, Johnson, A, Mutch, L, Yudkin, P, Johnson, P. Acid-base status at birth and neurodevelopmental outcome and four and one-half years. Am J Obstet Gynecol 1989; 161: 213–20.CrossRefGoogle ScholarPubMed
16Ruth, VJ, Raivio, KO. Perinatal brain damage: predictive value of metabolic acidosis and the Apgar score. Br Med J 1988; 297: 24–27.Google Scholar
17Sarnat, HB, Sarnat, MS. Neonatal encephalopathy following fetal distress. Arch Neurol 1976; 33: 696–705.CrossRefGoogle ScholarPubMed
18Amiel-Tison, C, Ellison, P. Birth Asphyxia in the full term newborn: early assessment and outcome. Dev Med Child Neurol 1986; 28: 671–82.CrossRefGoogle Scholar
19Levene, MI, Sands, C, Grindulis, H, Moore, JR. Comparison of two methods for predicting outcome in perinatal asphyxia. Lancet 1986; i: 67–91.Google Scholar
20Constantinou, JEC, Gillis, J, Ouvrier, RA, Rahilly, PM. Hypoxic-ischaemic encephalopathy after near miss sudden infant death syndrome. Arch Dis Child 1989; 64: 703–708.CrossRefGoogle ScholarPubMed
21Robertson, C, Finer, N. Term infants with hypoxic-ischaemic encephalopathy: outcome at 3.5 years. Dev Med Child Neurol 1985; 27: 473–84.CrossRefGoogle ScholarPubMed
22Harwood-Nash, DC, Flodmark, O. Diagnostic imaging of the neonatal brain: review and protocol. Am J Neuroradiol 1982; 3: 103–15.Google ScholarPubMed
23Fitzhardinge, PM, Flodmark, O, Fitz, CR, Ashby, S. The prognostic value of computed tomography as an adjunct to assessment of the term infant with postasphyxiai encephalopathy. J Pediatr 1981; 99: 777–81.Google Scholar
24Adsett, DB, Fitz, CR, Hill, A. Hypoxic-ischaemic cerebral injury in the term newborn: correlation of CT findings with neurological outcome. Dev Med Child Neurol 1985; 27 155–160.Google Scholar
25Chow, PP, Horgan, JG, Taylor, KJW. Neonatal periventricular leukomalacia: real-time sonographic diagnosis with CT correlation. AJNR 1985; 6: 383–88.Google Scholar
26Flodmark, O, Roland, EH, Hill, A, Whitfield, MF. Radiologie diagnosis of periventricular leukomalacia. Radiology 1987; 162 119–24.CrossRefGoogle Scholar
27Dubowitz, LMS, Bydder, GM, Mushin, J. Developmental sequence of periventricular leukomalacia: correlation of ultrasound, clinical and neuclear magnetic resonance functions. Arch Dis Child 1985; 60 349–55.CrossRefGoogle Scholar
28Barkkovich, AJ. MR and CT evaluation of profound perinatal and neonatal asphyxia. AJNR 1992; 13: 959–72.Google Scholar
29Baker, L, Stevenson, D, Enzmann, D. End stage periventricular leukomalacia: MR imaging evaluation. Radiology 1988; 168: 809–15.CrossRefGoogle Scholar
30Truwit, CL, Barkovich, AJ, Koch, TK, Ferreiro, DM. Cerebral palsy: MR findings in 40 patients. AJNR 1992; 13: 67–78.Google ScholarPubMed
31Volpe, JJ. Value of MR in definition of the neuropathology of cerebral palsy in vivo. AJNR 1992; 13: 79–83.Google ScholarPubMed
32Krageloh-Mann, I, Petersen, D, Hagberg, G, Vollmer, B, Hagberg, B, Michaelis, R. Bilateral. spastic cerebral palsy - MRI pathology and origin, analysis from a representative series of 56 cases. Dev Med Child Neurol 1995; 37: 379–97.CrossRefGoogle ScholarPubMed
33Nelson, KB, Ellenberg, JH. Obstetric complications as risk factors for cerebral or seizure disorders. JAMA 1984; 251: 1843–1848.CrossRefGoogle ScholarPubMed
34Holmes, G, Rowe, J, Hafford, J, Schmid, R, Testa, M, Zimmerman, A. Prognostic value of the encephalogram in neonatal asphyxia. Electroencephalogr Clin Neurophysiol 1982; 53: 60–72.CrossRefGoogle Scholar
35Watanabe, K, Miyazaki, S, Hara, K, Hakamadea, A. Behavioural state cycles, background EEG s and prognosis of newborns with perinatal hypoxia. Electroencephalogr Clin Neurophysiol 1980; 49: 618–25.CrossRefGoogle Scholar
36Bjerre, I, Helistrom-Westas, L, Rosen, I, Svenningsen, N. Monitoring of cerebral function after severe asphyxia in infancy. Arch Dis Child 1983; 58: 997–1002.CrossRefGoogle ScholarPubMed
37Eken, P, Toet, MC, Groenendaal, F, de Vries, LS. Predictive value of early neuroimaging, pulsed Doppler and neurophysiology in full term infants with hypoxic-ischaemic encephalopathy. Arch Dis Child 1995; 73: F75–F80.Google Scholar
38Connell, JA, Oozeer, R, Regev, R, de Vries, LS, Dubowitz, LMS, Dubowitz, V. Continuous 4 channel EEG monitoring in the evaluation of echodense ultrasound lesions and cystic leukomalacia. Arch Dis Child 1987; 62: 1019–26.CrossRefGoogle Scholar
39Wyatt, JS, Edwards, AD, Azzopardi, D, Reynolds, EOR. Magnetic resonance and near infrared spectroscopy for the investigation of perinatal hypoxic-ischaemic brain injury. Arch Dis Child 1989; 64 953–63.CrossRefGoogle ScholarPubMed
40Edwards, AD, Wyatt, JS, Richardson, EC, Delpy, DT, Cope, M, Reynolds, EOR. Cotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy. Lancet 1988; ii: 701–702.Google Scholar
41Wyatt, JS, Cope, M, Delpy, DT, Richardson, CE, Edwards, AD, Wray, S, Reynolds, EOR. Quantitation of cerebral blood volume in newborn human infants by near infrared spectroscopy. J Appi Physiol 1990; 68; 1086–91.CrossRefGoogle ScholarPubMed
42Wyatt, JS, Edwards, AD, Cope, M, Delpy, DT, McCormick, DC, Potter, A, Reynolds, EOR. Response of cerebral blood volume to changes in arterial carbon dioxide tension in preterm and term infants. Pediatr Res 1991; 29: 553–57.CrossRefGoogle ScholarPubMed
43Wyatt, JS. Near infrared spectroscopy in asphyxiai brain injury. Clin Perinatol 1993; 20: 369–78.CrossRefGoogle Scholar
44McCormick, DC, Edwards, AD, Roth, SC. Relation between cerebral hemodynamics and outcome in birth asphyxiated newborn infants studied by near infrared spectroscopy (abstract). Pediatr Res 1991; 30: 637.CrossRefGoogle Scholar
45Pryds, O, Greisen, G, Lou, H, Froos-Hansen, B. Vasoparalysis is associated with brain damage in asphyxiated term infants. J Pediatr 1990; 117: 119–25.Google Scholar
46Frewen, TC, Kissoon, N, Kroniek, J, Fox, M, Lee, R, Bradwin, N et al. Cerebral blood flow, cross-brain oxygen extraction and fontanelle pressure after hypoxic-ischaemic injury in newborn infants. J Pediatr 1991; 118: 265–71.CrossRefGoogle ScholarPubMed
47Archer, L, Levene, M, Evans, D. Cerebral artery doppler ultrasonography for prediction of outcome after perinatal asphyxia. Lancet 1986; ii: 1116–18.CrossRefGoogle Scholar
48Peebles, DM, Wyatt, JS. Near infrared spectroscopy and intrapartum fetal monitoring. Contemp Rev Obstet Gynaecol 1993; 5: 124–29.Google Scholar
49Aldrich, CA, D Antona, D, Spencer, JAD, Wyatt, JS. Near infrared spectroscopy used in the assessment of intrapartum fetal cerebral oxygénation. Contemp Rev Obstet Gynaecol 1995; 7: 71–76.Google Scholar
50Peebles, DM, Edwards, AD, Wyatt, JS, Bishop, AP, Cope, M, Delpy, DT et al. Changes in human fetal cerebral hemoglobin concentration and oxygenation during labor measured by near infrared spectroscopy. Am J Obstet Gynecol 1992; 166: 1369–73.CrossRefGoogle ScholarPubMed
51Aldrick, CJ, D'An tona, D, Wyatt, JS, Spencer, JAD, Peebles, DM, Reynolds, EOR. Fetal cerebral oxygénation measured by near infrared spectroscopy shortly before birth and acid-base status at birth. Obstet Gynecol 1994; 84: 861–66.Google Scholar
52Azzopardi, D, Wyatt, JS, Hamilton, PA, Cady, EB, Delpy, DT, Reynolds, EOR. Phosphorus metabolites and intracellular pH in the brains of normal and small-for-gestational-age infants investigated by magnetic resonance spectroscopy. Pediatr Res 1989; 25: 440–44.CrossRefGoogle ScholarPubMed
53Azzopardi, D, Wyatt, JS, Cady, EB, Delpy, DT, Batidin, J, Stewart, AL et al. Prognosis of newborn infants with hypoxic-ischaemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res 1989; 25: 445–51.CrossRefGoogle ScholarPubMed
54Moorcraft, J, Bolas, NM, Íves, NK et al. Spatially localised magnetic resonance spectroscopy of the brains of normal and asphyxiated newborns. Pediatrics 1991; 87: 273–82.Google Scholar
55Roth, SC, Edwards, AD, Cady, EB, Delpy, DT, Wyatt, JS, Azzopardi, D et al. Relation between cerebral oxidative metabolism following birth asphyxia and neurodevelopmental outcome at one year. Dev Med Child Neurol 1992; 34: 285–95.CrossRefGoogle ScholarPubMed
56Peden, CJ, Rutherford, MA, Sargentoni, J, Cox, IJ, Bryant, DJ, Dubowitz, LM. Proton spectroscopy of the neonatal brain following hypoxic-ischaemic injury. Dev Med Child Neurol 1993; 35: 502–10.Google Scholar
57Groenendaal, F, Veenhoven, RH, van der Grond, J, Jansen, GH, Witkamp, TD, de Vries, LS. Cerebral lactate and N-acetyl aspartate/choline ratios in asphyxiated full-term neonates demonstrated in vivo using proton magnetic resonance spectroscopy. Peadiatr Res 1994; 35: 148–51.Google Scholar
58Penrice, J, Cady, EB, Lorek, A, Wyelinska, M, Amess, PN, Aldridge, RF et al. Proton magnet resonance spectroscopy of the brain in normal preterai and term infants and early changes following perinatal hypoxia-ischaemia. Pediatr Res (in press).Google Scholar
59Lorek, A, Takei, Y, Cady, EB et al. Delayed cerebral energy failure following acute hypoxia-ischaemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetice resonance spectroscopy. Pediatr Res 1994; 36: 699–706.CrossRefGoogle Scholar
60Mehmet, H, Yue, X, Squier, MV et al. Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult. Neurosci Lett 1994; 181: 121–25.CrossRefGoogle Scholar
61Gluckman, PD, Williams, CE. When and why do brain cells die? Dev Med Child Neurol 1992; 34: 1010–1014.CrossRefGoogle ScholarPubMed
62McDonald, JW, Johnston, MV. Physiological and pathophysiological roles of excitatory aminoacids during central nervous system development. Brain 1990; 15: 41–70.Google ScholarPubMed
63Meldrum, B. Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission. Brain 1995; 2: 27–57.Google Scholar
64Levene, MI. Role of excitatory amino acid antogonists in the management of birth asphyxia. Biol Neonate 1992; 62: 248–51.Google Scholar
65McDonald, JW, Silverstein, FS, Johnston, MV. Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neurosci Lett 1990; 109: 234–38.CrossRefGoogle ScholarPubMed
66Silverstein, FS, Buchanan, K, ischaemia induced morphologic injury in inmature rat brain. Stroke 1986; 17: 477–82.CrossRefGoogle Scholar
67Gunn, AJ, Mydlar, T, Bennet, L, Fauli, RL, Gorter, S, Cook, C et al. The neuroprotective actions of a calcium channel antagonist, flunarazine, in the infant rat. Pediatr Res 1989; 25: 573–76.Google Scholar
68Levene, MI, Gibson, NA, Fenton, AC, Papathoma, E, Barnett, D. The use of a calcium-channel blocker, nicardipine, for severely asphyxiated newborn infants. Dev Med Child Neurol 1990; 32: 567–74.CrossRefGoogle ScholarPubMed
69Siesjo, BK, Agardh, CD, Bengtsson, F. Free radicals and brain damage. Brain 1989; 1: 165–211.Google Scholar
70Palmer, C, Vannucci, RC, Towfight, J. Reduction of perinatal hypoxic-ischaemic brain damage with allopurinol. Pediatr Res 1990; 27: 332–36.CrossRefGoogle ScholarPubMed
71Rosenburg, AA, Murdaugh, E, White, CW. The role of oxygen free radicals in postasphyxia cerebral hypoperfusion in newborn lambs. Pediatr Res 1989; 26: 215–19.CrossRefGoogle Scholar
72Guan, J, Williams, C, Gunning, M, Mallard, C, Gluckman, P. The effects of IGF-1 treatment after hypoxic-ischaemic brain injury in adult rats. J Cereb Blood Flow Metab 1993; 13: 609–16.CrossRefGoogle ScholarPubMed
73Colbourne, F, Carbett, D. Delayed and prolonged post-ischaemic hypothermia is neuroprotective in the gerbil. Brain Res 1994; 654: 265–72.Google Scholar
74Sirimanne, ES, Blumberg, RM, Bossano, D, Gunning, M, Edwards, AD, Gluckman, PD et al. The effect of prolonged modification of cerebral temperature on outcome following hypoxic-ischaemic brain injury in the infant rat. Pediatr Res 1995; (in press).CrossRefGoogle Scholar
75Thoresen, M, Penrice, J, Lorek, A, Cady, EB, Sylezinska, M, Kirkbride, V et al. Mild hypothermia following severe transient hypoxia-ischaemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res 1995; 37: 667–70.CrossRefGoogle Scholar
76Amess, PN, Penrise, J, Thoresen, M, Lorek, A, Kirkbride, V, Cooper, CE et al. Mild hypothermia after severe transient hypoxia-ischaemia reduces the delayed rise in cerebral lactate in the piglet (abstract) Pediatr Res 1995; 38: 423.Google Scholar