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Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine

Published online by Cambridge University Press:  13 February 2004

Yasuhiro Matsumura  and
Honnavara N. Ananthaswamy
Yasuhiro Matsumura
Affiliation:
Department of Immunology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 178, Houston, TX 77030, USA.
Honnavara N. Ananthaswamy
Affiliation:
Department of Immunology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 178, Houston, TX 77030, USA.
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Abstract

Acute ultraviolet (UV) irradiation of normal human skin results in several clinical effects, including sunburn inflammation (erythema) and tanning, histological changes such as thickening of the epidermis, and local or systemic immunosuppression. Chronic UV irradiation leads to photoaging, sustained immunosuppression and photocarcinogenesis. Photocarcinogenesis involves the accumulation of genetic changes, as well as immune system modulation, and ultimately leads to the development of skin cancers. Recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, the mutation of proto-oncogenes and tumour suppressor genes, and UV-induced immunosuppression. Further investigation and a better understanding of photocarcinogenesis are critical to the development of effective prevention and intervention strategies for human skin cancer.

Keywords

ultravioletUVacute effectchronic effectDNA repairp53apoptosisp16INK4ap19ARFpatchedras
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 4 , Issue 26 , 2 December 2002 , pp. 1 - 22
Copyright
© Cambridge University Press 2002

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