Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-26T22:51:45.935Z Has data issue: false hasContentIssue false
  • English
  • Français

PAR-2: structure, function and relevance to human diseases of the gastric mucosa

Published online by Cambridge University Press:  13 February 2004

Atsufumi Kawabata
Atsufumi Kawabata
Affiliation:
Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan.
Get access Rights & Permissions [Opens in a new window]

Abstract

PAR-2 (protease-activated receptor 2), a G-protein-coupled receptor activated by certain serine proteases such as trypsin and tryptase, is now considered a physiologically important molecule and also a novel target for drug development. PAR-2 is widely distributed in the mammalian body, especially throughout the alimentary system. PAR-2 plays various roles in the alimentary, circulatory, respiratory and neuronal systems. In the gastric mucosa, PAR-2 modulates multiple functions and exerts mucosal cytoprotection mainly by activating sensory neurons. Thus, PAR-2 would appear to be a therapeutic target for treatment of gastric mucosal injury. Agonists and/or antagonists for PAR-2 might also be applicable to the clinical treatment of patients with inflammatory diseases in other organs.

Keywords

protease-activated receptor (PAR)trypsintryptaseG-protein-coupled receptorgastric mucosal cytoprotectionpepsinacid secretionmucussensory neuronpeptic ulcer
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 4 , Issue 16 , 16 July 2002 , pp. 1 - 17
Copyright
© Cambridge University Press 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)