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GATA factors in vertebrate heart development and disease

Published online by Cambridge University Press:  15 September 2006

Alison Brewer  and
John Pizzey
Alison Brewer
Affiliation:
Cardiovascular Division, Department of Cardiology, King's College London School of Medicine, London, SE5 9PJ, UK
John Pizzey
Affiliation:
Wolfson Centre for Age-related Diseases, King's College London, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK
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Abstract

Vertebrate heart formation is dependent upon complex hierarchical gene regulatory networks, which effect both the specification and differentiation of cardiomyocytes and subsequently cardiac morphogenesis. GATA-4, -5 and -6 comprise an evolutionarily conserved subfamily of transcription factors, which are expressed within the precardiac mesoderm from early stages in its specification and continue to be expressed within the adult heart. We review here the functional roles of individual GATA transcription factors in cardiac development, normal homeostasis and disease. We also review the cellular mechanisms employed to regulate the expression and downstream targets of the different GATA factors.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 8 , Issue 22 , September 2006 , pp. 1 - 20
Copyright
© 2006 Cambridge University Press

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