Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury

Fardad T. Afshari; Sunil Kappagantula; James W. Fawcett

doi:10.1017/S1462399409001288

Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury

Published online by Cambridge University Press: 08 December 2009

Fardad T. Afshari ,

Sunil Kappagantula and

James W. Fawcett

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Fardad T. Afshari*: Affiliation:
Centre for Brain Repair, University of Cambridge, Cambridge, UK.
Sunil Kappagantula: Affiliation:
Centre for Brain Repair, University of Cambridge, Cambridge, UK.
James W. Fawcett: Affiliation:
Centre for Brain Repair, University of Cambridge, Cambridge, UK.
*: *Corresponding author: Fardad T. Afshari, Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK. Tel: +44 1223 334121; Fax: +44 1223 331174; E-mail: [email protected]

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Abstract

Spinal cord injury is one of the most devastating conditions that affects the central nervous system. It can lead to permanent disability and there are around two million people affected worldwide. After injury, accumulation of myelin debris and formation of an inhibitory glial scar at the site of injury leads to a physical and chemical barrier that blocks axonal growth and regeneration. The mammalian central nervous system thus has a limited intrinsic ability to repair itself after injury. To improve axonal outgrowth and promote functional recovery, it is essential to identify the various intrinsic and extrinsic factors controlling regeneration and navigation of axons within the inhibitory environment of the central nervous system. Recent advances in spinal cord research have opened new avenues for the exploration of potential targets for repairing the cord and improving functional recovery after trauma. Here, we discuss some of the important key molecules that could be harnessed for repairing spinal cord injury.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 11 , July 2009 , e37

DOI: https://doi.org/10.1017/S1462399409001288 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2009

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Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury

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Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury

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