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Diverse functions of BRCA1 in the DNA damage response

Published online by Cambridge University Press:  12 February 2004

Jong-Soo Lee  and
Jay H. Chung
Jong-Soo Lee
Affiliation:
Department of Life Sciences, College of Natural Sciences, Hanyang University, Seoul 133-791, South Korea.
Jay H. Chung
Affiliation:
Laboratory of Molecular Hematology, National Heart Lung and Blood Institute, Building 10-7D13, NIH, 10 Center Drive, Bethesda, MD 20892-1654, USA.
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Abstract

Breast cancer is one of the most common causes of cancer-related mortality in women. It affects more than one in nine women over their lifetime. Although most breast cancers are sporadic, the genetics and molecular biology of the heritable forms of breast cancer have provided valuable insights into not only breast cancer but also cancers in general. Among the mutations linked to heritable breast cancers, the mutations in the breast cancer 1 (BRCA1) gene are the best characterised. The BRCA1 gene encodes a nuclear protein that is important for maintaining genome integrity. However, a growing list of BRCA1-associated proteins suggests that BRCA1 has diverse and unexpected functions.

Keywords

BRCA1ATMATRCds1Chk2phosphorylationDNA damagekinasecheckpointcancer
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 3 , Issue 15 , 18 May 2001 , pp. 1 - 11
Copyright
© Cambridge University Press 2001

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