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Chemokines in cancer

Published online by Cambridge University Press:  12 February 2004

Mitchell J. Frederick  and
Gary L. Clayman
Mitchell J. Frederick
Affiliation:
Department of Head and Neck Research, University of Texas M.D. Anderson Cancer Center, 1515 Box Holcombe, Box 69, Houston, TX 77030, USA.
Gary L. Clayman
Affiliation:
Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, 1515 Box Holcombe, Box 69, Houston, TX 77030, USA.
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Abstract

Chemokines are small, chemotactic cytokines that direct migration of leukocytes, activate inflammatory responses and participate in many other pleiotropic functions, including regulation of tumour growth. Chemokines modulate tumour behaviour by three important mechanisms: regulation of tumour-associated angiogenesis, activation of a host tumour-specific immunological response, and direct stimulation of tumour cell proliferation in an autocrine fashion. All of these mechanisms are promising points of cancer intervention, and preclinical mouse models suggest that chemokine antagonists and agonists could become important in the development of new anticancer therapies.

Keywords

chemokinecancertumourtumortumour vaccinetumor vaccineangiogenesisdendritic cellcytokinechemotaxis
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 3 , Issue 19 , 18 July 2001 , pp. 1 - 18
Copyright
© Cambridge University Press 2001

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