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PAR-2: structure, function and relevance to human diseases of the gastric mucosa

Published online by Cambridge University Press:  13 February 2004

Atsufumi Kawabata
Atsufumi Kawabata
Affiliation:
Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan.
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Abstract

PAR-2 (protease-activated receptor 2), a G-protein-coupled receptor activated by certain serine proteases such as trypsin and tryptase, is now considered a physiologically important molecule and also a novel target for drug development. PAR-2 is widely distributed in the mammalian body, especially throughout the alimentary system. PAR-2 plays various roles in the alimentary, circulatory, respiratory and neuronal systems. In the gastric mucosa, PAR-2 modulates multiple functions and exerts mucosal cytoprotection mainly by activating sensory neurons. Thus, PAR-2 would appear to be a therapeutic target for treatment of gastric mucosal injury. Agonists and/or antagonists for PAR-2 might also be applicable to the clinical treatment of patients with inflammatory diseases in other organs.

Keywords

protease-activated receptor (PAR)trypsintryptaseG-protein-coupled receptorgastric mucosal cytoprotectionpepsinacid secretionmucussensory neuronpeptic ulcer
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 4 , Issue 16 , 16 July 2002 , pp. 1 - 17
Copyright
© Cambridge University Press 2002

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