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Molecular mechanisms of learning and memory

Published online by Cambridge University Press:  13 February 2004

Jane Dunning  and
Matthew J. During
Jane Dunning
Affiliation:
Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1001, New Zealand.
Matthew J. During
Affiliation:
Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1001, New Zealand.
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Abstract

Memory is the process by which organisms are able to record their experiences, and use this information to adapt their responses to the environment. As such, it is vital for survival. In recent years, the development of spatially and temporally selective techniques for the regulation of gene expression has allowed the molecular details of this process to emerge. Here we review the molecular mechanisms thought to underlie memory acquisition and storage, as well as discuss recent evidence regarding the mechanisms of subsequent memory consolidation.

Keywords

memorylearninglong-term potentiationN-methyl-D-aspartate receptorNMDA receptorcalcium-calmodulin kinase IICaMKIIcalcineurinCREB
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 5 , Issue 25 , 7 October 2003 , pp. 1 - 11
Copyright
© Cambridge University Press 2003

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