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The Malaria Genome Sequencing Project

Published online by Cambridge University Press:  11 February 2004

Daniel J. Carucci ,
Malcolm J. Gardner ,
Herve Tettelin ,
Leda M. Cummings ,
Hamilton O. Smith ,
Mark D. Adams ,
Stephen L. Hoffman  and
J. Craig Venter
Daniel J. Carucci
Affiliation:
Malaria Program, Naval Medical Research Institute, 12300 Washington Avenue, Rockville, MD 20852, USA.
Malcolm J. Gardner
Affiliation:
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Herve Tettelin
Affiliation:
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Leda M. Cummings
Affiliation:
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Hamilton O. Smith
Affiliation:
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Mark D. Adams
Affiliation:
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Stephen L. Hoffman
Affiliation:
Malaria Program, Naval Medical Research Institute, 12300 Washington Avenue, Rockville, MD 20852, USA.
J. Craig Venter
Affiliation:
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
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Abstract

An international consortium of genome centres, advanced development teams and funding agencies has begun the task of sequencing the genome of the parasite Plasmodium falciparum, the most important cause of human malaria. Sequencing is proceeding chromosome by chromosome, and the annotated sequence of chromosome 2 is nearly finished. With the continual release of sequence data as they are generated, malaria researchers have access to a steady stream of genomic sequences and will soon have the complete annotation of all of the estimated 5000–7000 P. falciparum genes. The task will then be how to best apply these data to the development of new anti-malarial drugs, vaccines and diagnostic tests. This review provides a brief overview of the Malaria Genome Sequencing Project and suggests potential directions for future malaria research.

Keywords

malariaPlasmodium falciparumgenomeMalaria Genome Sequencing Projectchromosomesequencemap
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 1 , Issue 3 , 5 May 1998 , pp. 1 - 9
Copyright
© Cambridge University Press 1998

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