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Herpes simplex virus latency

Published online by Cambridge University Press:  13 February 2004

Robin Lachmann
Robin Lachmann
Affiliation:
Wellcome Clinician Scientist Fellow, Department of Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.
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Abstract

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are ubiquitous human pathogens. They share with other herpesviruses the ability to establish lifelong latent infection of the host. Periodic reactivation from latency is responsible for most of the clinical disease burden of HSV infection. This review focuses on what we have learned from molecular studies in model systems of HSV latency, and the implications these findings have for treating recurrent HSV disease.

Keywords

herpes simplex virusHSVlatencyreactivation
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 5 , Issue 29 , 5 December 2003 , pp. 1 - 14
Copyright
© Cambridge University Press 2003

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