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Transgenic animals in cardiovascular disease research

Published online by Cambridge University Press:  10 January 2001

Michael Bader ,
Holger Bohnemeier ,
Frank S. Zollmann ,
Ora E. Lockley-Jones  and
Detlev Ganten
Michael Bader
Affiliation:
Max-Delbrück-Center for Molecular Medicine (MDC), D-13092 Berlin-Buch, Department of Clinical Pharmacology, Benjamin Franklin University Hospital, Free University D-12200 Berlin, Germany and Department of Natural Sciences, Albany State University, Albany, GA 31705, USA
Holger Bohnemeier
Affiliation:
Max-Delbrück-Center for Molecular Medicine (MDC), D-13092 Berlin-Buch, Department of Clinical Pharmacology, Benjamin Franklin University Hospital, Free University D-12200 Berlin, Germany and Department of Natural Sciences, Albany State University, Albany, GA 31705, USA
Frank S. Zollmann
Affiliation:
Max-Delbrück-Center for Molecular Medicine (MDC), D-13092 Berlin-Buch, Department of Clinical Pharmacology, Benjamin Franklin University Hospital, Free University D-12200 Berlin, Germany and Department of Natural Sciences, Albany State University, Albany, GA 31705, USA
Ora E. Lockley-Jones
Affiliation:
Max-Delbrück-Center for Molecular Medicine (MDC), D-13092 Berlin-Buch, Department of Clinical Pharmacology, Benjamin Franklin University Hospital, Free University D-12200 Berlin, Germany and Department of Natural Sciences, Albany State University, Albany, GA 31705, USA
Detlev Ganten
Affiliation:
Max-Delbrück-Center for Molecular Medicine (MDC), D-13092 Berlin-Buch, Department of Clinical Pharmacology, Benjamin Franklin University Hospital, Free University D-12200 Berlin, Germany and Department of Natural Sciences, Albany State University, Albany, GA 31705, USA
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Abstract

Worldwide, the highest morbidity and mortality results from such cardiovascular diseases as hypertension, myocardial infarction, cardiac and renal failure, as well as stroke. Since the cardiovascular system and its regulation is quite complex, study of these disorders has been grossly limited to whole organism models. As a result, in recent years, transgenic technology has played a significant role in the discovery of specific gene products for cardiovascular regulation and disease aetiology. Genetic manipulation in rats and mice has altered the expression of numerous genes. In this review, some of the important new genetically modified animals (i.e. transgenic models) with alterations in hormone and second messenger systems involved in cardiovascular regulation are summarized.

Type
Research Article
Information
Experimental Physiology , Volume 85 , Issue 6 , November 2000 , pp. 713 - 731
Copyright
© The Physiological Society 2000

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