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A simple method for generating a blood pressure-unit activity relationship for central cardiovascular neurons in the rat

Published online by Cambridge University Press:  21 August 2002

A. Cividjian ,
N. Rentero ,
R. McAllen  and
L. Quintin
A. Cividjian
Affiliation:
Physiology, School of Medicine, Lyon, France, Neurophysiology, Howard Florey Institute, Melbourne, Australia and Anesthesia, University of Pennsylvania, Philadelphia, PA, USA
N. Rentero
Affiliation:
Physiology, School of Medicine, Lyon, France, Neurophysiology, Howard Florey Institute, Melbourne, Australia and Anesthesia, University of Pennsylvania, Philadelphia, PA, USA
R. McAllen
Affiliation:
Physiology, School of Medicine, Lyon, France, Neurophysiology, Howard Florey Institute, Melbourne, Australia and Anesthesia, University of Pennsylvania, Philadelphia, PA, USA
L. Quintin
Affiliation:
Physiology, School of Medicine, Lyon, France, Neurophysiology, Howard Florey Institute, Melbourne, Australia and Anesthesia, University of Pennsylvania, Philadelphia, PA, USA
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Abstract

One way to identify central cardiovascular neurons is to consider their barosensitivity, for example by plotting changes in their single unit activity as a function of evoked changes in blood pressure. To simplify the genesis of such pressure-activity relationships, a coronary angioplasty catheter was threaded into the aorta of anaesthetized rats and the balloon inflated to raise the blood pressure mechanically. Here, such a procedure is exemplified for cardiac vagal motoneurons in the medulla oblongata in eight rats. This simplification bypasses potentially problematic surgery and minimizes deterioration of the animal. Experimental Physiology (2002) 87.5, 535-538.

Type
Full Length Papers
Information
Experimental Physiology , Volume 87 , Issue 5 , September 2002 , pp. 535 - 538
Copyright
© The Physiological Society 2002

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