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Ziprasidone-induced priapism requiring surgical treatment

Presented in part at the 13th Congress of the Association of European Psychiatrists Munich, Germany, April 2–6, 2005

Published online by Cambridge University Press:  16 April 2020

Kenneth R. Kaufman ,
Lauren Stern ,
Arash Mohebati ,
Aviva Olsavsky  and
Jonathan Hwang
Kenneth R. Kaufman*
Affiliation:
Department of Psychiatry, UMDNJ-Robert Wood Johnson Medical School, 125 Paterson Street, Suite #2200, New Brunswick, NJ 08901, USA Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, 125 Paterson Street, Suite #2200, New Brunswick, NJ 08901, USA
Lauren Stern
Affiliation:
Department of Psychiatry, UMDNJ-Robert Wood Johnson Medical School, 125 Paterson Street, Suite #2200, New Brunswick, NJ 08901, USA
Arash Mohebati
Affiliation:
Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, 125 Paterson Street, Suite #2200, New Brunswick, NJ 08901, USA
Aviva Olsavsky
Affiliation:
Department of Psychiatry, UMDNJ-Robert Wood Johnson Medical School, 125 Paterson Street, Suite #2200, New Brunswick, NJ 08901, USA
Jonathan Hwang
Affiliation:
Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, 125 Paterson Street, Suite #2200, New Brunswick, NJ 08901, USA
*
*Corresponding author. Tel.: +1 732 235 7647; fax: +1 732 235 7677. E-mail address:[email protected] (K.R. Kaufman).
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Abstract

Both typical and atypical antipsychotic psychotropics have been reported to cause ischemic priapism presumptively secondary to alpha1-adrenergic blockade. This condition is a urologic emergency for if not evaluated and treated appropriately, long-term sequelae include erectile dysfunction and impotence. This paper addresses the first reported case of priapism requiring surgical intervention presumed to be secondary to ziprasidone. Increased clinician and patient education regarding priapism is required in order to minimize this adverse event and to maximize immediate treatment.

Keywords

ZiprasidonePriapismTreatmentShuntAtypical antipsychoticsErectile dysfunction
Type
Short communication
Information
European Psychiatry , Volume 21 , Issue 1 , January 2006 , pp. 48 - 50
Copyright
Copyright © Elsevier SAS 2006

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References

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th Ed.Washington, DC: American Psychiatric Association; 1994.Google Scholar
Compton, MTMiller, AHPriapism associated with conventional and atypical antipsychotic medications: a review. J. Clin. Psychiatry 2001;62(5):362–366.CrossRefGoogle ScholarPubMed
Dahm, PRao, DSDonatucci, CFAntiandrogens in the treatment of priapism. Urology 2002;59(1):138.CrossRefGoogle ScholarPubMed
El-Bahnasawy, MSDawood, AFarouk, ALow-flow priapism: risk factors for erectile dysfunction. BJU Int. 2002;89(3):285–290.CrossRefGoogle ScholarPubMed
Greenberg, WMLee, KKPriapism treated with benztropine. Am. J. Psychiatry 1987;144:384–385.Google ScholarPubMed
Harmon, WNehra, APriapism: diagnosis and management. Mayo Clin. Proc. 1997;72(4):350–355.CrossRefGoogle ScholarPubMed
Keoghane, SRSullivan, MEMiller, MAWThe aetiology, pathogenesis and management of priapism. BJU Int. 2002;90(2):149–154.CrossRefGoogle ScholarPubMed
Melman, ASerel, SPriapism. Int. J. Impot. Res. 2000;12(4):S133–S139.CrossRefGoogle ScholarPubMed
Montague, DKJarow, JBroderick, GADmochowski, RRHeaton, JPLue, TFet al.American Urological Association guideline on the management of priapism. J. Urol. 2003;170(4, Part 1):1318–1324.CrossRefGoogle Scholar
Nixon, RGO’Connor, JLMilan, DFEfficacy of shunt surgery for refractory low flow priapism: a report on the incidence of failed detumescence and erectile dysfunction. J. Urol. 2003;170(3):883–886.CrossRefGoogle ScholarPubMed
Pais, VMAyvazian, PJPriapism from quetiapine overdose: first report and proposal of mechanism. Urology 2001;58(3):462.CrossRefGoogle Scholar
Reeves, RRMack, JEPriapism associated with two atypical antipsychotic agents. Pharmacotherapy 2002;22(8):1070–1073.CrossRefGoogle ScholarPubMed
Reeves, RRKimble, RProlonged erections associated with ziprasidone treatment: a case report. J. Clin. Psychiatry 2003;64(1):97–98.CrossRefGoogle ScholarPubMed
Vitke, GMHarrigan, RAUfberg, JWChan, TCEmergency evaluation and treatment of priapism. J. Emerg. Med. 2004;26(3):325–329.Google Scholar
Winter, CCPriapism cured by creation of fistulas between glans penis and corpora cavernosa. J. Urol. 1978;119:227–228.CrossRefGoogle ScholarPubMed
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