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Virtual Reality Cognitive Remediation for Mood disorders: RCT pilot study

Published online by Cambridge University Press:  01 September 2022

L. Lipskaya-Velikovsky ,
D. Cohen ,
D. Livian-Carmel  and
G. Eger
L. Lipskaya-Velikovsky*
Affiliation:
The Hebrew University of Jerusalem, Occupational Therapy, Jerusalem, Israel Beer Yaakov - Ness Ziona Mental Health Center, Occupational Therapy, Beer Yaakov, Israel
D. Cohen
Affiliation:
Geha Mental Health Center, Occupational Therapy, Petah Tikva, Israel School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Occupational Therapy, Tel Aviv, Israel
D. Livian-Carmel
Affiliation:
School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Occupational Therapy, Tel Aviv, Israel
G. Eger
Affiliation:
Geha Mental Health Center, Psychiatry, Petah Tikva, Israel Tel Aviv University, Sackler Faculty Of Medicine, Tel Aviv, Israel
*
*Corresponding author.

Abstract

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Introduction

Mood disorders interrupt well-being and participation in everyday activities through, among others, a mechanism of cognitive impairments. Ample evidence was found for cognitive remediation (CR) effectiveness in various mental health conditions. However, its contribution to improvement of functional outcomes in mood disorders was little investigated. Virtual Reality (VR)-based CR has a potential to overcome limitations by enabling training on daily-life tasks in ecological environments.

Objectives

Test the effectiveness of VR-based vs standard CR for improvement of cognition, functional capacity and participation in daily-life activities in mood disorders.

Methods

Twenty-two individuals (female: N=13, 59.1%; Age: M=39, SD=13.4) diagnosed with major depression or bipolar disorder were randomly assigned either to the standard or VR-based CR. The participants completed 6 half-an-hour sessions using the Functional Brain Trainer (Intendu©), a body-controlled, adaptive tool for training of inhibition, planning, working memory, shifting, self-initiation, persistence, and attention in functional tasks and environments. Standard assessments were used to evaluate cognition, functional capacity, mood symptoms and participation dimensions in pre-post design.

Results

VR-based CR contributes to improvement in memory, executive functions and construction (2<Z<2.23, p<.05), functional capacity (Z=-2.44, p<.01) and satisfaction with participation (Z= -1.9, p<.01). Standard CR contributes to executive functions (Z=2.33, p<.05), and functional capacity (Z=-2.35, p<.05).

Conclusions

This study provides initial evidence for contribution of CR to functional outcomes in mood disorders, with advantages of VR-based modality, suggesting the potential of CR to improve treatment outcomes and well-being in this population. Larger, controlled trials are needed to further expand evidence for VR-based CR effectiveness.

Disclosure

No significant relationships.

Keywords

Everyday functioningMood disordersCognitive remediation
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S145
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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