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Verapamil treatment in clozapine-induced sleep-related enuresis: a case report

Published online by Cambridge University Press:  16 April 2020

M Pojurovsky ,
M Schneidman ,
M Mark  and
A Weizman
M Pojurovsky
Affiliation:
Sha’ar Menashe Psychiatric Hospital, Hadera Tirat Camel Psychiatric Hospital, Haifa
M Schneidman
Affiliation:
Tirat Camel Psychiatric Hospital, Haifa
M Mark
Affiliation:
Mental Health Services, Israel Ministry of Health
A Weizman*
Affiliation:
Research Unit, Geha Psychiatric Hospital, and Felsenstein Medical Research Center, Beilinson Medical Center, PO Box 102, Sackler Faculty of Medicine, Tel Aviv University, Petah Tiqva49100, Israel
*
*Correspondence and reprints.
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Summary

Enuresis is an embarrassing rare side effect of clozapine treatment. Using single-blind placebo-control design, the antienuretic activity of the calcium channel blocker verapamil (up to 80 mg/day per os, at 21.00 hours) was evaluated in a schizophrenic patient with comorbid obsessive-compulsive disorder (OCD) who developed nocturnal functional enuresis during clozapine treatment. Verapamil (80 mg/day) displayed antienuretic activity. No correlation between the bradycardiac effect and the antienuretic activity of verapamil was detected.

Keywords

enuresisclozapineverapamil
Type
Case report
Information
European Psychiatry , Volume 10 , Issue 8 , 1995 , pp. 413 - 415
Copyright
Copyright © Elsevier, Paris 1995

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References

Cohen, MAAlfonso, CAMosquera, MDevelopment of urinary retention during treatment with clozapine and meclizine. Am J Psych 1994; 151: 619–20Google ScholarPubMed
Ferrie, BGMactarlane, JGlen, ESDDAVP in young enuretic patients: a double blind trial. Br J Urol 1984; 56: 376–8CrossRefGoogle ScholarPubMed
Goton, MHassouna, MElhilali, MIntravesical instillation of verapamil and its effect on detrusor contractility. In vitro and in vivo studies. J Urology 1986; 135: 218AGoogle Scholar
Grinshpoon, AMark, MApter, AModai, IBleich, ARehavi, MWeizman, AFailure of fixed-dose verapamil treatment in adult sleep-related enuresis. Eur Psychiatry 1994; 9: 101–3CrossRefGoogle Scholar
Kuchenhoff, BDie wichtigsten Nebenwirkungen unter clozapine (Leponex) und ihre Behandlung. Psychiatr Praxis 1993; 20: 201–6Google Scholar
Liberman, JAKane, JMJohns, CAClozapine: guidelines for clinical management. J Clin Psychiatry 1989; 50: 329–38Google Scholar
Merschel, AOberle, JRangoni, FLa clozapine effects indesirables: étude dans les CHS de la région Alsace. La Pharmac Hosp Franc 1993; 106: 231–42Google Scholar
Mozes, TToren, PChernuzan, N, et al. Clozapine treatment in very early onset schizophrenia. J Am Acad Child Adolesc Psychiatry 1994; 33: 65–70CrossRefGoogle ScholarPubMed
Palmer, TWorth, PExton-Smith, AFlunarizine: a once-daily therapy for urinary incontinence. Lancet 1981; 8: 279–81CrossRefGoogle Scholar
Safferman, AUpdate on the clinical efficacy and side effects of clozapine. Schizophren Bull 1991; 17: 247–61CrossRefGoogle ScholarPubMed
Rud, TAnderson, REUlmster, UEffects of nifedipine in women with unstable bladder. Urol Int 1979; 34: 421–9CrossRefGoogle Scholar
Safferman, AUpdate on the clinical efficacy and side effects of clozapine. Schizophren Bull 1991; 17: 247–61CrossRefGoogle ScholarPubMed
Warner, JPHarvey, CABarnes, TREClozapine and urinary incontinence. Int Clin Psychopharmacol 1994; 9: 207–9CrossRefGoogle ScholarPubMed
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