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Ventricle volumes in emerging psychosis. A cross-sectional and longitudinal MRI study

Published online by Cambridge University Press:  16 April 2020

G.E. Berger ,
S.J. Wood ,
D. Velakoulis ,
A. Ang ,
W.J. Brewer ,
L.J. Phillips ,
A.R. Yung ,
T.M. Proffitt ,
C. Pantelis  and
P.D. McGorry
G.E. Berger
Affiliation:
ORYGEN Research Centre, University of Melbourne, Melbourne, VIC, Australia Department of Psychiatry, University Hospital, Basel, Switzerland
S.J. Wood
Affiliation:
ORYGEN Research Centre, University of Melbourne, Melbourne, VIC, Australia Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia
D. Velakoulis
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia
A. Ang
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia
W.J. Brewer
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia
L.J. Phillips
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia Department of Psychology, University of Melbourne, Melbourne, VIC, Australia
A.R. Yung
Affiliation:
ORYGEN Research Centre, University of Melbourne, Melbourne, VIC, Australia
T.M. Proffitt
Affiliation:
ORYGEN Research Centre, University of Melbourne, Melbourne, VIC, Australia
C. Pantelis
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia
P.D. McGorry
Affiliation:
ORYGEN Research Centre, University of Melbourne, Melbourne, VIC, Australia

Abstract

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Objective

Ventricular enlargement is one of the most consistent brain changes associated with schizophrenia. However, there are only few cross-sectional studies in genetic at risk individuals, and no studies in individuals meeting ultra high risk (UHR) criteria of developing frank psychosis. This study investigates the timing of ventricular volume changes across the different stages of emerging psychotic disorders.

Methods

We measured ventricular volumes in 473 subjects comparing 135 UHR subjects (of whom 39 subsequently developed a psychotic illness), 162 first-episode psychosis (FEP) subjects, 89 chronic schizophrenia (CS) subjects with 87 normal controls (NC). 29 UHR, 25 FEP, 13 CS, and 24 HV had longitudinal follow up scans.

Results

We found significant ventricular enlargement in FEP and CS, but not in UHR and NC. Longitudinal analysis confirmed ventricular enlargement in non-affective psychosis only. UHR patients had normal ventricular volumes regardless of whether they made transition to frank psychosis or not.

Conclusion

Our results are suggestive that ventricular enlargement is a consequence of transition and/or progression of illness rather than a risk marker in that it is apparent only after the onset of frank psychosis, with prominence in patients with schizophrenia-like psychoses. The results parallel our previous study in that hippocampal volumes were reduced in CS and normal in patients having non-schizophrenic psychoses as well in UHR individuals.

Type
S18. Symposium: Can we Improve the Prediction of the Onset of Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S30 - S31
Copyright
Copyright © European Psychiatric Association 2007
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