Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-26T22:40:29.997Z Has data issue: false hasContentIssue false
  • English
  • Français

Utilization patterns of antidepressants between 1991 and 2011 in a population-based cohort of middle-aged and elderly

Published online by Cambridge University Press:  15 April 2020

N. Aarts ,
R. Noordam ,
A. Hofman ,
H. Tiemeier ,
B.H. Stricker  and
L.E. Visser
N. Aarts
Affiliation:
Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040 3000CA, Rotterdam, The Netherlands
R. Noordam
Affiliation:
Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040 3000CA, Rotterdam, The Netherlands
A. Hofman
Affiliation:
Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040 3000CA, Rotterdam, The Netherlands Netherlands Consortium of Healthy Ageing, P.O. Box 2040, Rotterdam, The Netherlands
H. Tiemeier
Affiliation:
Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040 3000CA, Rotterdam, The Netherlands Department of Psychiatry, Erasmus Medical Center, P.O. Box 2040, Rotterdam, The Netherlands Department of Child and Adolescent Psychiatry, Erasmus Medical Center, P.O. Box 2040Rotterdam, The Netherlands
B.H. Stricker*
Affiliation:
Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040 3000CA, Rotterdam, The Netherlands Netherlands Consortium of Healthy Ageing, P.O. Box 2040, Rotterdam, The Netherlands Inspectorate of Health Care, P.O. Box 2040, the Hague, The Netherlands
L.E. Visser
Affiliation:
Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040 3000CA, Rotterdam, The Netherlands Apotheek Haagse Ziekenhuizen – HAGA, P.O. Box 2040, The Hague, The Netherlands
*
*Corresponding author. E-mail address:[email protected] (B.H. Stricker).
Get access

Abstract

Background

In middle-aged and older patients in whom antidepressant use increased in last decades, patterns of use might be of concern The objective of this study was to investigate the patterns of prevalence, incidence and duration of antidepressant use in an ageing population.

Methods

All participants (aged > 45 years) from the population-based Rotterdam Study were followed from January 1st 1991 until death, loss to follow-up, or end of the study period (December 31st 2011). Antidepressant drug dispensing, based on pharmacy records, were subdivided into Tricyclic Antidepressants (TCAs), Selective Serotonin Reuptake Inhibitors (SSRIs) and other antidepressants. One-year prevalence, 5-year incidence and duration of antidepressant use were calculated.

Results

Yearly prevalence of antidepressant use increased from 3.9% in 1991 to 8.3% of the population in 2011. The increase in SSRI use was 5.8-fold, whereas use of other antidepressants doubled and TCA use remained stable over time. Incidence of all antidepressants decreased from 23.9 to 14.2 per 1000 person-years between 1992 and 2011. The duration of a first treatment episode increased over time.

Conclusion

Despite the prevalence of antidepressant use increased over time, incidence did not, which is most likely explained by a longer treatment duration and recurrent episodes.

Keywords

Antidepressant agentsDrug utilizationMiddle-aged and elderly
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 6 , August 2014 , pp. 365 - 370
Copyright
Copyright © Elsevier Masson SAS 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1

Tel.: +31 10 70 44229; fax.: 31 10 70 44657

2

Tel.: +31 10 70 43488; fax.: 31 10 70 44657

3

Tel.: +31 10 07 04 3489; fax.: 31 10 70 44657

4

Tel.: +31 10 70 44294; fax.: 31 10 70 44657

References

Anderson, I.M., Ferrier, I.N., Baldwin, R.C., Cowen, P.J., Howard, L., Lewis, G.et al.Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines. J Psychopharmacol 2008;22(4):343–396 [Epub 2008 Apr 15].CrossRefGoogle ScholarPubMed
Bouhassira, D., Lantéri-Minet, M., Attal, N., Laurent, B., Touboul, C.Prevalence of chronic pain with neuropathic characteristics in the general population. Pain 2008;136(3):380–387.CrossRefGoogle ScholarPubMed
Chemali, Z., Chahine, L.M., Fricchione, G.The use of selective serotonin reuptake inhibitors in elderly patients. Harv Rev Psychiatr 2009;17(4):242–253 [Review].CrossRefGoogle ScholarPubMed
Coupland, C., Dhiman, P., Morriss, R., Arthur, A., Barton, G., Hippisley-Cox, J.Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ 2011;343:d4551.CrossRefGoogle ScholarPubMed
Des, S.Are antidepressants overprescribed? Yes. BMJ 2013;32(15):346 [2013–01–2223].Google Scholar
Egberts, A.C., Leufkens, H.G., Hofman, A., Hoes, A.W.Incidence of antidepressant drug use in older adults and association with chronic diseases: the Rotterdam Study. Int Clin Psychopharmacol 1997;12(4):217–223.CrossRefGoogle ScholarPubMed
Egberts, A.C., Veenstra, M., de Jong-van den Berg, L.T.Antidepressant drug choice for first users in two regions in The Netherlands. Pharm World Sci 1999;21(3):132–136.CrossRefGoogle ScholarPubMed
Gardarsdottir, H., Heerdink, E.R., Egberts, A.C.Potential bias in pharmacoepidemiological studies due to the length of the drug free period: a study on antidepressant drug use in adults in the Netherlands. Pharmacoepidemiol Drug Saf 2006;15(5):338–343.CrossRefGoogle Scholar
Gardarsdottir, H., Souverein, P.C., Egberts, T.C., Heerdink, E.R.Construction of drug treatment episodes from drug-dispensing histories is influenced by the gap length. J Clin Epidemiol 2010;63(4):422–427.CrossRefGoogle ScholarPubMed
Hansen, D.G., Rosholm, J.U., Gichangi, A., Vach, W.Increased use of antidepressants at the end of life: population-based study among people aged 65 years and above. Age Ageing 2007;36(4):449–454.CrossRefGoogle ScholarPubMed
Hemels, M.E., Koren, G., Einarson, T.R.Increased use of antidepressants in Canada: 1981–2000. Ann Pharmacother 2002;36(9):1375–1379.CrossRefGoogle ScholarPubMed
Het College voor zorgverzekeringen Aantal gebruikers 2007–2011 voor ATC-subgroep N06A: Antidepressiva Genees- en hulpmiddelen Informatie Project (GIP) College voor zorgverzekeringen 2011 [updated 15-05-2012; cited 2013 11th of March]; 2011. http://gipdatabank.nl/.Google Scholar
Hofman, A., Grobbee, D.E., De Jong, P.T.V.M., Van den Ouweland, F.A.Determinants of disease and disability in the elderly: The Rotterdam Elderly Study. Eur J Epidemiol 1991;7(4):403–422.CrossRefGoogle ScholarPubMed
Hofman, A., Murad, S., Duijn, C., Franco, O., Goedegebure, A., Arfan Ikram, M.et al.The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol 2013 1–38. [2013/11/21].Google ScholarPubMed
Ian, C.R.Are antidepressants overprescribed? No. BMJ 2013;32(15):346. [2013–01–2223].Google Scholar
Kengetallen, S.F. Jaaroverzicht Data en Feiten. Stichting Farmaceutische Kengetallen; Yearly edition. [updated 2012; cited 2013 6th of February]2013. http://www.sfk.nl/nieuws-publicaties/data-en-feiten.Google Scholar
Kompas, F. Amitriptyline (Neuropatische pijn). Farmacotherapeutisch Kompas. [updated 2012; cited 2012 1st of February] 2012. http://www.fk.cvz.nl/.Google Scholar
Landelijke Stuurgroep Multidisciplinaire Richtlijnontwikkeling (GGZ) Richtlijnherziening van de Multidisciplinaire richtlijn Depressie (eerste revisie). Richtlijn voor de diagnostiek behandeling en begeleiding van volwassen patiënten met een depressieve stoornis. Utrecht: Trimbos Instituut; 2005.Google Scholar
Landelijke Stuurgroep Multidisciplinaire Richtlijnontwikkeling (GGZ) Addendum ouderen bij de MDR depressie. [Versie 1.0] 2008 Trimbos-instituut; Utrecht.Google Scholar
Marwijk, H.W.J., van, G.H., Brueren, M.M., Sigling, H.O., Stolk, J., Gelderen, M.G., van, et al.NHG-Standaard Depressie. Huisarts Wet 1994;37:482–490.Google Scholar
Meijer, W.E., Heerdink, E.R., Leufkens, H.G., Herings, R.M., Egberts, A.C., Nolen, W.A.Incidence and determinants of long-term use of antidepressants. Eur J Clin Pharmacol 2004;60(1):57–61.CrossRefGoogle ScholarPubMed
Mojtabai, R., Olfson, M.Proportion of antidepressants prescribed without a psychiatric diagnosis is growing. Health Aff (Millwood) 2011;30(8):1434–1442.CrossRefGoogle ScholarPubMed
Moore, M., Yuen, H.M., Dunn, N., Mullee, M.A., Maskell, J., Kendrick, T.Explaining the rise in antidepressant prescribing: a descriptive study using the general practice research database. BMJ 2009 339.Google ScholarPubMed
Olfson, M., Marcus, S.C., Pincus, H.A., Zito, J.M., Thompson, J.W., Zarin, D.A.Antidepressant prescribing practices of outpatient psychiatrists. Arch Gen Psychiatry 1998;55(4):310–316.CrossRefGoogle ScholarPubMed
Parabiaghi, A., Franchi, C., Tettamanti, M., Barbato, A., D’Avanzo, B., Fortino, I.et al.Antidepressants utilization among elderly in Lombardy from 2000 to 2007: dispensing trends and appropriateness. Eur J Clin Pharmacol 2011;67(10):1077–1083.CrossRefGoogle ScholarPubMed
Piek, E., van der Meer, K., Nolen, W.A.Guideline recommendations for long-term treatment of depression with antidepressants in primary care – a critical review. Eur J Gen Pract 2010;16(2):106–112.CrossRefGoogle ScholarPubMed
Raymond, C.B., Morgan, S.G., Caetano, P.A.Antidepressant utilization in British Columbia from 1996 to 2004: increasing prevalence but not incidence. Psychiatr Serv 2007;58(1):79–84.CrossRefGoogle Scholar
Roberts, R.E., Kaplan, G.A., Shema, S.J., Strawbridge, W.J.Does growing old increase the risk for depression?. Am J Psychiatry 1997;154(10):1384–1390.Google ScholarPubMed
Rosholm, J.U., Andersen, M., Gram, L.F.Are there differences in the use of selective serotonin reuptake inhibitors and tricyclic antidepressants? A prescription database study. Eur J Clin Pharmacol 2001;56(12):923–929.CrossRefGoogle ScholarPubMed
Serna, C., Galván, C.I., Real, L., Gascó, J., Soler-González, E.J.Evolution of the prevalence and incidence of consumption of antidepressants in a Spanish region (2002–2007). Ment Health Fam Med 2010;7(1):9–15.Google Scholar
Sihvo, S., Isometsa, E., Kiviruusu, O., Hamalainen, J., Suvisaari, J., Perala, J.et al.Antidepressant utilisation patterns and determinants of short-term and non-psychiatric use in the Finnish general adult population. J Affect Disord 1101–22008 94–105.CrossRefGoogle ScholarPubMed
Sonnenberg, C.M., Deeg, D.J., Comijs, H.C., van Tilburg, W., Beekman, A.T.Trends in antidepressant use in the older population: results from the LASA-study over a period of 10 years. J Affect Disord 1112–32008 299–305.CrossRefGoogle Scholar
van Eijk, M.E., Bahri, P., Dekker, G., Herings, R.M., Porsius, A., Avorn, J.et al.Use of prevalence and incidence measures to describe age-related prescribing of antidepressants with and without anticholinergic effects. J Clin Epidemiol 2000;53(6):645–651.CrossRefGoogle ScholarPubMed
van Marwijk, H.W., Bijl, D., Ader, H.J., de Haan, M.Antidepressant prescription for depression in general practice in The Netherlands. Pharm World Sci 2001;23(2):46–49.CrossRefGoogle ScholarPubMed
Van Marwijk, H.W.J.G.H, Bijl, D., Van Gelderen, M.G., De Haan, M., Van Weel-Baumgarten, E.M., Burgers, J.S., Boukes, F.S., Romeijnders, A.C.M.NHG-Standaard depressieve stoornis (depressie). Huisarts Wet 2003;46(11):614–633.Google Scholar
Submit a response

Comments

No Comments have been published for this article.