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Treatment of early episode in patients with schizophrenia: the role of long acting antipsychotics

Published online by Cambridge University Press:  15 April 2020

S. Heres ,
M. Lambert  and
R. Vauth
S. Heres*
Affiliation:
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Technischen Universität München, Ismaningerstraße 22 München81675Germany
M. Lambert
Affiliation:
Psychosis Centre, Department of Psychiatry and Psychotherapy Centre of Psychosocial Medicine University Medical Centre Hamburg-Eppendorf Martinistraße 52 Hamburg20251Germany
R. Vauth
Affiliation:
Psychiatric University Clinics University of Basel, Centre for Mental Health Kornhausgasse 7 Basel4051Switzerland
*
*Corresponding author: Klinik und Poliklinik für Psychiatrie und Psychotherapie der Technischen Universität München, Ismaningerstraße 22, 81675 München, Germany. Tel.: + 49 89 4140 4227; fax: + 49 89 4140 7339.[email protected]

Abstract

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The use of long-acting injectable antipsychotics (LAIs) in schizophrenia is usually restricted to patients in long-term treatment, who prefer them to oral antipsychotics, and to patients with multiple relapses who have a history of non-adherence. However, preliminary evidence from patients in the early phases of the disease suggest that second generation LAIs may be superior to second generation oral medications with regard to the control of negative symptoms and psychosocial functioning. Moreover, several studies have found that psychiatrists are generally reluctant to prescribe LAI antipsychotics and under-estimate their acceptability by patients. Key elements to take into account when offering a LAI in the early course of schizophrenia should include their potential superiority in allowing early detection of non-adherence and in reducing the number of rehospitalisations and relapses.

Keywords

SchizophreniaAntipsychoticLong-acting injectionsFirst episodeRecent onset
Type
Review
Information
European Psychiatry , Volume 29 , Issue S2: Treatment of early episode in patients with schizophrenia: the role of long acting antipsychotics , November 2014 , pp. 1409 - 1413
Copyright
Copyright © European Psychiatric Association 2014

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