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Tianeptine counteracts the anxiogenic effects of benzodiazepine withdrawal, but not those of exposure to cat odour

Published online by Cambridge University Press:  16 April 2020

SE File ,
N Andrews  and
H Zangrossi Jr
SE File
Affiliation:
Psychopharmacology Research Unit, UMDS Division of Pharmacology, Guy's Hospital, LondonSEI 9RT, UK
N Andrews
Affiliation:
Psychopharmacology Research Unit, UMDS Division of Pharmacology, Guy's Hospital, LondonSEI 9RT, UK
H Zangrossi Jr
Affiliation:
Psychopharmacology Research Unit, UMDS Division of Pharmacology, Guy's Hospital, LondonSEI 9RT, UK
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Summary

Tianeptine is a clinically effective anti-depressant with the unusual profile of increasing 5-HT uptake, thereby decreasing the synaptic availability of 5-HT. In the social interaction test of anxiety in the rat, withdrawal from chronic diazepam treatment produced a significant anxiogenic response that was reversed by acute administration of tianeptine (2.5–10 mg/kg). These doses were without significant effect in the vehicle-treated rats. Exposure of rats to cat odour resulted in anxiogenic responses in the plus-maze and social interaction tests and in decreased exploration. These changes were not reversed by 5 days treatment with tianeptine (2.5–10 mg/kg). Thus, tianeptine may not he effective in all anxiety states, but could be particularly useful in treating patients withdrawn from benzodiazepines.

Keywords

anxietybenzodiazepine withdrawal5-HT release5-HT uptaketianeptine
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 75s - 80s
Copyright
Copyright © Elsevier, Paris 1993

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References

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