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Tianeptine: clinical properties

Published online by Cambridge University Press:  16 April 2020

H Lôo ,
B Delalleau  and
A Kamoun
H Lôo
Affiliation:
SHU de Santé Mentale el de Thérapeutique, Hôpital Sainte-Anne, I, rue Cabanis, 75014Paris
B Delalleau
Affiliation:
IRIS, 6, place des Pléiades, 92415Courbevoie Cedex, France
A Kamoun
Affiliation:
IRIS, 6, place des Pléiades, 92415Courbevoie Cedex, France
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Summary

Tianeptine has been shown to be an effective antidepressant versus reference drugs and to be better tolerated than amitriptyline, without the latter's anticholinergic side-effects. Its good acceptability has been confirmed in long-term use (1 year) in large patient groups. In an open pilot trial in endogenous melancholia, tianeptine showed the same activity as would be expected of a conventional antidepressant. This is being verified in a double-blind trial versus maprotiline. In a separate open study, it has demonstrated a potential to prevent relapse and recurrence in depressed patients treated for 1 year. These results are currently being tested versus placebo.

Keywords

depressionrelapserecurrencetianeptine
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 103s - 109s
Copyright
Copyright © Elsevier, Paris 1993

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References

Andreasen, NCScheftner, WReich, THirschfeld, RMAEndicott, JKeller, MB (1986) The validation of the concept of endogenous depression. Arch Gen Psychiatry 43, 246–251CrossRefGoogle ScholarPubMed
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM III), Washington DC, APAGoogle Scholar
Bersani, GPasini, ABrancato, TValducci, MCiani, N (1989) Serotonina e depressione: studio multicentrico controllato tianeptina versus amitriptilinaXXXVII Congresso Nazionale della Società Italiana di Psichiatria Rome, February 6-11 1989. CIC Edizioni Internazionali, 1243–1249Google Scholar
Bourgeois, MDelalleau, BFéline, AGinestet, DLôo, HVan Amerongen, P (1991) Étude de la tianeptine dans les épisodes dépressifs majeurs avec mélancolie et signes d'endogénicité Presse Méd 37, 1837–1843Google Scholar
Carney, MWPRoth, MGarside, RF (1965) The diagnosis of depressive syndromes and the prediction of ECT response Br J Psychiatry 111, 659–674CrossRefGoogle Scholar
Chapuy, PCuny, GDelomier, VGalley, PMichel, JPParraud, MMarey, C (1991) La dépression du sujet âgé. Intérêt de la tianeptine chez 140 patients traités pendant un an Presse Méd 37, 1844–1852Google Scholar
Derogatis, LRLipman, RSRickels, KUhlenhuth, RHCovi, L(1974) The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory Behav Sci 19, 1–15CrossRefGoogle ScholarPubMed
Disalver, SC (1989) Antidepressant withdrawal syndromes. Phenomenology and pathopsychology Acta Psychiatr Scand 79, 113–117Google Scholar
Food and Drug Administration (1977) Guidelines for the Clinical Evaluation of Antianxiety DrugsGoogle Scholar
Ganry, HMarey, CDelalleau, BLe Moine, PKamoun, A (1991) Tianeptine: a new antidepressantIn: Biological Markers of Depression: state-of-the-art (Ansseau, Mvon Frenckell, RFranck, G eds). Elsevier, Amsterdam, 203–208Google Scholar
Guelfi, JD (1992) Efficacy of tianeptine in comparative trials versus reference antidepressants: an overview Br J Psychiatry 160(suppl 15), 72–75CrossRefGoogle Scholar
Guelfi, JDDreyfus, JFPull, CB (1983) A check list for the assessment of somatic symptoms (CHESS). Principal component and cluster analysis. 7th World Congress of Psychiatry, Vienna, Abstracts, Ciba-Geigy, p. 454Google Scholar
Guelfi, JDDulcire, CLe Moine, PTafani, A (1992) Clint cal safety and efficacy of tianeptine in 1858 depressed patients treated in general practice Neuropsychobiology 25, 140–148CrossRefGoogle Scholar
Guelfi, JDPichot, PDreyfus, JF (1989) Efficacy of tianeptine in anxious-depressed patients: results of a controlled multicenter trial versus amitriptyline Neuropsychobiology 22, 41–48CrossRefGoogle ScholarPubMed
Hamilton, M (1959) The assessment of anxiety states by rating Br J Psychol 32, 50–55CrossRefGoogle ScholarPubMed
Hamilton, M (1960) A rating scale for depression J Neurol Neurosurg Psychiatry 23, 56CrossRefGoogle Scholar
Hamilton, M (1969) Standardized assessment and recording of depressive symptoms Psychiatr Neurol Neurosurg 72, 201–205Google Scholar
Hirschfeld, RMACross, CK (1987) Clinical psychopathology and diagnosis in relation to treatment of affective disordersIn: Psychopharmacology: the Third Generation of Progress (Meltzer, HY ed). Raven Press, New York, 1021–1029Google Scholar
Lendresse, PCren, MCLe Marie, JC (1985) Traitement prolongé par Alival 85 mg dans les états dépressifs névrotiques et réactionnels Psychiat Française 16 (suppl), 156–158Google Scholar
Lôo, HGanry, HDufour, HGuelfi, JDMalka, ROlié, JPScharbach, HTignol, JMarey, CKamoun, A (1992) Long-term treatment with tianeptine in 380 depressed patients Br J Psychiatry 160 (suppl 15), 61–65CrossRefGoogle Scholar
Lôo, HGanry, HDufour, HMalka, ROlié, JPKamoun, ADeniker, P (1992) Rôle de la tianeptine dans la prévention des rechutes et récidives dépressives Presse Med 20, 1864–1868Google Scholar
Lôo, HGanry, HMarey, CBriole, GCastelnau, DCharbonnier, JFDachary, JMDanion, JMDarcourt, GCapdeville, CDufour, HSouche, AEscande, MFavre, JDFéline, AGuelfi, JDLéger, JMMalauzat, DLemoine, PMalka, ROlié, JPDe Praingy, MScharbach, HScotto, JCTignol, JKamoun, A (1990) Acceptabilité et efficacité thérapeutique de la tianeptine chez 510 patients traités un an JAMA (French edn) special issue November, 44–53Google Scholar
Lôo, HMalka, RDefrance, RBarrucand, DBenard, JYNiox-Rivière, HRaab, ASarda, AVachonfrance, GKamoun, A (1988) Tianeptine and amitriptyline: controlled double-blind trial in depressed alcoholic patients Neuropsychohiology 19, 79–85CrossRefGoogle ScholarPubMed
Malka, R (1988) Role of drug therapies in the treatment of alcoholism: alcohol and anxiety-alcohol and depression Clin Neuropharmacol 11 (suppl 2), S69–S73Google ScholarPubMed
Mindham, RHSHowland, CShepherd, M (1973) An evaluation of continuation therapy with tricyclic antidepressant in depressive illness Psychol Med 3, 5–17CrossRefGoogle ScholarPubMed
Montgomery, SAÅsberg, MA (1979) A new depression scale designed to be sensitive to change Br J Psychiatry 134,382–389CrossRefGoogle ScholarPubMed
Montgomery, SADufour, HBrion, SGailledreau, JLaqueille, XFerrey, GMoron, PParant-Lucena, NSinger, LDanion, JMBenzen, JNPierredon, MA (1988) The prophylactic efficacy of fluoxetine in unipolar depression Br J Psychiatry 153 (suppl 3), 69–75CrossRefGoogle Scholar
Ostaptzeff, G (1981) Étude contrôlée á double insu versus imipramine de l'efficacité de la tianeptine dans des états dépressifs non-psychotiques In: Biological Psychiatry 1981. Proceedings of the IIIrd World Congress of Biological Psychiatry, June 28-July 3, 1981, Stockholm, Sweden. Elsevier/North Holland, 597–600Google Scholar
Overall, JEGorham, DR (1962) The brief psychiatry rating scale Psychol Rep 10, 799–812CrossRefGoogle Scholar
Prien, RFKupfer, DJMansky, PASmall, JGTuason, VBVoss, CBJohnson, WE (1984) Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders Arch Gen Psychiatry 41, 1096–1104CrossRefGoogle ScholarPubMed
Stein, MKRickels, KWeise, CC (1980) Maintenance therapy with amitriptyline: a controlled trial Am J Psychiatry 137,370–371Google ScholarPubMed
Weiss, CGorceix, AKindynis, SDimitriu, M (1981) Étude contrôlée à double insu versus nomifensine de l'activité et du délai d'action d'un nouvel antidépresseur, la tianeptineIn: Biological Psychiatry 1981. Proceedings of the IIIrd World Congress of Biological Psychiatry June 28-July 3, 1981, Stockholm, Sweden. Elsevier/North Holland, 593–596Google Scholar
Weissman, MMMyers, JK (1980) Clinical depression in alcoholism Am J Psychiatry 137, 372–373Google ScholarPubMed
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