Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-28T10:38:02.041Z Has data issue: false hasContentIssue false
  • English
  • Français

Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients☆

Published online by Cambridge University Press:  15 April 2020

O. Kampman ,
O. Poutanen ,
A. Illi ,
E. Setälä-Soikkeli ,
M. Viikki ,
T. Nuolivirta  and
E. Leinonen
O. Kampman*
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Seinäjoki Hospital District, Department of Psychiatry, Seinäjoki, Finland
O. Poutanen
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Tampere University Hospital, Department of Psychiatry, 33014Tampere, Finland
A. Illi
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland
E. Setälä-Soikkeli
Affiliation:
Kanta-Häme Central Hospital, Department of Psychiatry, Hämeenlinna, Finland
M. Viikki
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Tampere Mental Health Centre, Tampere, Finland
T. Nuolivirta
Affiliation:
Seinäjoki Hospital District, Department of Psychiatry, Seinäjoki, Finland
E. Leinonen
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Tampere University Hospital, Department of Psychiatry, 33014Tampere, Finland
*
*Corresponding author.Tel.: +358 44 4155547(mobile); fax: +358 3 35516164. E-mail address: [email protected] (O. Kampman).
Get access

Abstract

Objective

The Temperament and Character Inventory (TCI) is commonly used in adult populations. Our aim was to explore: (1) if there are specific differences in temperament dimensions related to depression in comparison with general population, (2) if the treatment response during the acute phase of major depressive disorder (MDD) is predictable by TCI temperament dimensions.

Method

Temperament profiles in 98 MDD patients were compared with a Finnish community sample. The patients were treated with serotonin selective reuptake inhibitors (SSRIs) for 6weeks and their temperament profiles were assessed at baseline and endpoint. The harm avoidance (HA) and depression scores at baseline and endpoint were modelled with path analysis. For path modelling, we tested the relationships between different temperament dimensions and depression symptoms and other clinical variables with Mancova model.

Results

The HA scores were significantly higher in patients both at baseline and endpoint compared to the Northern Finland 1966 Birth Cohort (NFBC). The patients, and especially males, had slightly higher reward dependency (RD) scores. HA at endpoint explained moderately the Montgomery Åsberg Depression Rating Scale (MADRS) endpoint score. HA endpoint score was strongly explained by HA baseline score.

Conclusions

HA is associated with risk of and treatment response to depression.

Keywords

TemperamentInventoriesMajor depressionAntidepressive agentsSecond generationTherapeutic use
Type
Original article
Information
European Psychiatry , Volume 27 , Issue 4 , May 2012 , pp. 245 - 249
Copyright
Copyright © Elsevier Masson SAS 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agosti, V., McGrath, P.J.Comparison of the effects of fluoxetine, imipramine and placebo on personality in atypical depression. J Affect Disord. 2002; 71: 113–120.CrossRefGoogle ScholarPubMed
Carmody, T.J., Rush, A.J., Bernstein, I., Warden, D., Brannan, S., Burnham, D.et al.The Montgomery Åsberg and the Hamilton ratings of depression: a comparison of measures. Eur Neuropsychopharmacol. 2006; 16: 601–611.CrossRefGoogle ScholarPubMed
Celikel, F.C., Kose, S., Cumurcu, B.E., Erkorkmaz, U., Sayar, K., Borckardt, J.J.et al.Cloninger's temperament and character dimensions of personality in patients with major depressive disorder. Compr Psychiatry. 2009; 50: 556–561.CrossRefGoogle ScholarPubMed
Cloninger, C.R., Bayon, C., Svrakic, D.M.Measurement of temperament and character in mood disorders: a model of fundamental states as personality types. J Affect Disord. 1998; 51: 21–32.CrossRefGoogle Scholar
Cloninger, C.R., Svrakic, D.M., Przybeck, T.R.A psychobiological model of temperament and character. Arch Gen Psychiatry. 1993; 50: 975–990.CrossRefGoogle ScholarPubMed
Cloninger, C.R., Przybeck, T.R., Svrakic, D.M.The tridimensional personality questionnaire: US normative data. Psychol Rep. 1991; 69: 1047–1057.CrossRefGoogle Scholar
Corruble, E., Duret, C., Pelissolo, A., Falissard, B., Guelfi, J.D.Early and delayed personality changes associated with depression recovery? A one-year follow-up study. Psychiatry Res. 2002; 109: 17–25.CrossRefGoogle ScholarPubMed
de Winter, R.F.P., Wolterbeek, R., Spinhoven, P., Zitman, F.G., Goekoop, J.G.Character and temperament in major depressive disorder and a highly anxious-retarded subtype derived from melancholia. Compr Psychiatry. 2007; 48: 426–435.CrossRefGoogle Scholar
Elovainio, M., Kivimaki, M., Puttonen, S., Heponiemi, T., Pulkki, L., Keltikangas-Jarvinen, L.Temperament and depressive symptoms: a population-based longitudinal study on Cloninger's psychobiological temperament model. J Affect Disord. 2004; 83: 227–232.CrossRefGoogle ScholarPubMed
Farmer, A., Mahmood, A., Redman, K., Harris, T., Sadler, S., McGuffin, P.A sib-pair study of the Temperament and Character Inventory scales in major depression. Arch Gen Psychiatry. 2003; 60: 490–496.CrossRefGoogle ScholarPubMed
Grucza, R.A., Przybeck, T.R., Spitznagel, E.L., Cloninger, C.R.Personality and depressive symptoms: a multidimensional analysis. J Affect Disord. 2003; 74: 123–130.CrossRefGoogle Scholar
Gutierrez, F., Torrens, M., Boget, T., Martin-Santos, R., Sangorrin, J., Perez, G.et al.Psychometric properties of the Temperament and Character Inventory (TCI) questionnaire in a Spanish psychiatric population. Acta Psychiatr Scand. 2001; 103: 143–147.CrossRefGoogle Scholar
Hirano, S., Sato, T., Narita, T., Kusunoki, K., Ozaki, N., Kimura, S.et al.Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution. J Affect Disord. 2002; 69: 31–38.CrossRefGoogle ScholarPubMed
Kose, S., Sayar, K., Kalelioglu, U., Aydin, N., Celikel, F.C., Gulec, H.et al.Normative data and factorial structure of the Turkish version of the Temperament and Character Inventory. Compr Psychiatry. 2009; 50: 361–368.CrossRefGoogle ScholarPubMed
Menza, M.A., Forman, N.E., Goldstein, H.S., Golbe, L.I.Parkinson's disease, personality, and dopamine. J Neuropsychiatry Clin Neurosci. 1990; 2: 282–287.Google ScholarPubMed
Miettunen, J., Kantojarvi, L., Ekelund, J., Veijola, J., Karvonen, J.T., Peltonen, L.et al.A large population cohort provides normative data for investigation of temperament. Acta Psychiatr Scand. 2004; 110: 150–157.CrossRefGoogle ScholarPubMed
Miettunen, J., Veijola, J., Lauronen, E., Kantojärvi, L., Joukamaa, M.Sex differences in Cloninger's temperament dimensions – a meta-analysis. Compr Psychiatry. 2007; 48: 161–169.CrossRefGoogle ScholarPubMed
Montgomery, S.A., Åsberg, M.A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979; 134: 382–389.CrossRefGoogle ScholarPubMed
Mulder, R.T.Personality pathology and treatment outcome in major depression: a review. Am J Psychiatry. 2002; 159: 359–371.CrossRefGoogle ScholarPubMed
Peirson, A.R., Heuchert, J.W., Thomala, L., Berk, M., Plein, H., Cloninger, C.R.Relationship between serotonin and the temperament and character inventory. Psychiatry Res. 1999; 89: 29–37.CrossRefGoogle ScholarPubMed
Pelissolo, A., Corruble, E.Personality factors in depressive disorders: contribution of the psychobiologic model developed by Cloninger. Encephale. 2002; 28: 363–373.Google ScholarPubMed
Richter, J., Eisemann, M., Richter, G.Temperament and character during the course of unipolar depression among inpatients. Eur Arch Psychiatry Clin Neurosci. 2000; 250: 40–47.CrossRefGoogle ScholarPubMed
Sato, T., Narita, T., Hirano, S., Kusunoki, K., Sakado, K., Uehara, T.Is interpersonal sensitivity specific to non-melancholic depressions?. J Affect Disord. 2001; 64: 133–144.CrossRefGoogle ScholarPubMed
Smith, D.J., Duffy, L., Stewart, M.E., Muir, W.J., Blackwood, D.H.High harm avoidance and low self-directedness in euthymic young adults with recurrent, early-onset depression. J Affect Disord. 2005; 87: 83–89.CrossRefGoogle ScholarPubMed
Snaith, R.P., Harrop, F.M., Newby, D.A., Teale, C.Grade scores of the Montgomery Åsberg Depression and the Clinical Anxiety Scales. Br J Psychiatry. 1986; 148: 599–601.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.